精神分裂症病人的外周血免疫学参数  

Immunologic parameters in peripheral blood of schizophrenics

作　　者：程宇航[1] 谢家康[1] 陈学诗[1] 凌四海[1] 徐敏杰[1] 翁永振[1] 秦英绂[1] 陈建生[1] 黄淑贞[1] 刘瑞玫[1] 

机构地区：[1]北京市安定医院

出　　处：《上海精神医学》1998年第2期76-78,共3页Shanghai Archives of Psychiatry

摘　　要：为探讨不同亚型精神分裂症患者的免疫功能状态,对41例病人(Ⅰ型21人、Ⅱ型20人)T细胞亚群、NK细胞CD56的表达、白细胞介素4(IL—4)及可溶性白细胞介素2受体(sIL—2R)进行检测,并以15例健康人为对照。结果显示,Ⅰ型患者CD3+、CD4+细胞数、CD4/CD8比值显著低于对照组(P<0.01,P<0.05,P<0.01),CD56+细胞数、sIL—2R显著高于对照组(P<0.01,P<0.05);Ⅱ型患者CD8+细胞数明显升高(P<0.01),CD4/CD8比值下降(P<0.01),而CD56+、CD3+、CD4+、IL—4、sIL—2R与正常人无显著差别,两型精神分裂症病人血IL—4与对照组比无显著性差异。提示:精神分裂症患者存在细胞免疫功能改变,而这种免疫功能改变与精神分裂症的分型有关。To examine the immune status of the patients with different subtypes of schizophreni-a. Methods: 41 patients (21 subtype I , 20 subtype I ) and 15 healthy controls had been tested for T-cell subsets, NK-cell expressed CD56, Interleukin-4 and soluble interleukin-2 receptor (sIL-2R) in peripheral blood. The results were compared with normal controls. Results: Subtype I patients had lower CD3 + ,CD4+ lymphocytes and the ratio of CD4/CD8 (P<0. 01, P<0. 05, P<0. 001X, higher percentage of CD56+ cell and sIL-2R(P<0. 01,P<0. 05); wherea subtype I patients with higher CD8+ lymphocytes (P<0. 01) and lower ratio of CD4/CD8(P<0. 01). Both Subtypes had no significant IL-4 changes. Conclusion: Schizophrenic patients might have some cellular immunolog-ic abnormalities, which are relevant to different subtypes of schizophrenia.

关 键 词：T细胞亚群 CD56细胞 精神分裂症 SIL-2R 

分 类 号：R749.3[医药卫生—神经病学与精神病学]