惊恐障碍局部脑血流灌注的研究  

A neuroimaging study of regional cerebral blood flow on panic disorder

作　　者：李惠春[1] 马颖[1] 周君富[1] 闻树群[1] 孙达[1] 王立伟[2] 

机构地区：[1]浙江医科大学附属二院 [2]上海医科大学

出　　处：《上海精神医学》1998年第2期69-72,共4页Shanghai Archives of Psychiatry

摘　　要：目的 探讨惊恐障碍(PD)与局部脑血流(rCBF)改变的关系及其可能的生物学机制。方法 对16例PD患者及15名正常对照者应用单光子发射计算机断层摄影技术测定rCBF灌注。结果 PD患者rCBF灌注异常的阳性率为100％(16/16),低灌注多见于双侧前下额叶和下颞叶、右侧枕叶及左侧基底节;其中双侧额叶、右侧颞叶及左基底节的rCBF降低与Hamilton焦虑量表评分呈直线负相关。结论 提示皮层-纹状体神经环路在PD的神经病理生理机制中起重要作用。To evaluate the changes of regional cerebral blood flow (rCBF) in panic disorder (PD). Methods: Single photon emmission computed tomography(SPECT) was performed in 16 cases of PD and 15 normal volunteers. Results: Comapared with normal group, panic patients showed significantly decreased rCBF in the following regions; bilateral inferior frontal and temporal cortices, right occipital cortex and left basal ganglia. Regional perfusion indices of patients were negatively correlated with the scores of Hamilton anxiety scale in both frontal lobes, right temporal cortex and left basal ganglia. Conclusion: These results suggest that the dysfunction of cortex-striatum pathway plays an important role in neuropathophysiological mechanism of PD.

关 键 词：惊恐障碍 局部脑血流 神经影像学 

分 类 号：R749.7[医药卫生—神经病学与精神病学]