前列腺干细胞抗原在胰腺癌神经浸润转移中作用的研究  

Role of prostate stem cell antigen in perineural invasion of pancreatic carcinoma

作　　者：孟令新[1] 丁兆军[1] 陈希平[1] 张红[1] 迟玉华[1] 王丰松[1] 

机构地区：[1]济宁医学院附属日照市人民医院肿瘤科山东省日照市肿瘤治疗中心,276826

出　　处：《中国医药》2009年第7期481-482,共2页China Medicine

基　　金：国家自然科学基金资助项目（30801051）;山东省日照市人民医院博士科研启动基金资助项目（080901）

摘　　要：目的探讨前列腺干细胞抗原（PSCA）在人胰腺癌神经浸润中的作用。方法80例胰腺癌手术标本切片HE染色，观察记数小血管、小淋巴管、神经纤维浸润数。用鼠抗人PSCA单抗行免疫组化二步法染色，观察肿瘤细胞的阳性情况。结果肿瘤细胞神经浸润阳性与小血管、小淋巴管的浸润呈正相关（r=0．978，r=0．548，P〈0．01或P〈0．05）；肿瘤细胞PSCA表达阳性（53例）与神经浸润阳性（66例）呈正相关（r=0．746，P〈0．01）；肿瘤的恶性程度与PSCA表达呈正相关；PSCA表达与小血管、小淋巴管浸润无关。结论PSCA可能是胰腺癌的特征性分子之一。它可引导胰腺癌细胞向神经纤维趋化和黏附，即起“导航”和“停泊”作用。Objective To investigate the role of prostate stem cell antigen （PSCA） in perineural invasion of pancreatic carcinoma. Methods Eighty patients with pancreatic carcinoma were analyzed with histopathologic and immunohistochemical （SABC） methods. The overall PSCA expression rate, perineural, lymphatic and vascular vessel invasion were recorded. Results Perineuret invasion was positively correlated with lymphatic and vascular vessel invasion（ P 〈 0.01 ）. A positive correlation was found between tumor PSCA expressioa （53 cases） and perineurel invasion （66 cases）. A definite correlation was also found between cancer differentiation and PSCA expression. Conclusion PSCA is one of the most important molecules and may play a role as a ＂navigating＂ and ＂docking＂ molecule in progress of perineural invasion.

关 键 词：胰腺肿瘤 前列腺干细胞抗原 神经浸润 

分 类 号：R735.9[医药卫生—肿瘤]