偏头痛患者5-羟色胺2A受体启动子区T102C基因多态性的研究  

Analysis of the 5-HT2A receptor promoter T102C gene polymorphisms in migraine patients

作　　者：关珂[1] 张黎明[1] 代亚美[1] 李莹[1] 周云军[1] 王晓丽[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经内科,黑龙江哈尔滨150001

出　　处：《中风与神经疾病杂志》2009年第3期340-342,共3页Journal of Apoplexy and Nervous Diseases

基　　金：哈尔滨医科大学第一临床医学院科研基金资助项目(编号:B08-014)

摘　　要：目的探讨5-羟色胺2A受体(5-HT2AR)基因T102C多态性与哈尔滨地区汉族人偏头痛的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测204例偏头痛患者及186例健康对照者5-HT2AR基因启动子区域T102C多态性。结果偏头痛患者中T/T,T/C,C/C分布为29.9%,53.9%和16.2%,正常对照中T/T,T/C,C/C分布为35.0%,48.9%和16.1%,两组间无显著性差异(P>0.05)。偏头痛患者的等位基因频率为102T56.9%,102C43.1%,正常对照组为102T59.4%,102C40.6%,两组间无显著性差异(P>0.05)。结论5-HT2AR基因启动子区域T102C基因多态性与哈尔滨地区汉族人偏头痛的发生无相关性。Objective To investigate the association between 5-HT2A receptor （5-HT2AR） promoter T102C gene polymorphism and migraine in Han nationality, Harbin. Methods Polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP）analysis were applied to determine the genotypes at the promoter 102 of 5-HT2AR gene in 204 migraine patients and 186 controls. The genotype distribution and allele frequencies among different groups were compared. Results The genotype T/T,T/C,C/C distribution of the 5-HT2AR were 29.9% ,53.9% and 16.2% in migraine patients, and were 35.0% ,48.9% and 16.1% in controls （ P 〉 0.05 ）. The allele frequencies of 5-HT2AR in migraine patients were 56.9% for 102T,43.1% for 102C,and 59.4% for 102T,40.6% for 102C in controls（P 〉0.05）. Conclusion The polymorphism of 5-HT2AR promoter T102C gene was not significantly associated with migraine among Han nationality, in Harbin, China.

关 键 词：5-羟色胺2A受体 偏头痛 基因多态性 

分 类 号：R747.2[医药卫生—神经病学与精神病学]