HER2、Ki-67、TK1蛋白在脑膜瘤中的表达  

Expression of HER2,Ki-67 and TK1 Protein in Meningiomas

作　　者：王珊珊[1] 梅金红[2] 王淳良[3] 徐姗[2] 徐林林[2] 熊一峰[2] 张宝红[2] 

机构地区：[1]南昌大学研究生院医学部,2006级南昌330006 [2]南昌大学第一附属医院病理科,南昌330006 [3]南昌大学第一附属医院脑外科,南昌330006

出　　处：《江西医学院学报》2009年第4期32-35,39,F0003,共6页Acta Academiae Medicinae Jiangxi

摘　　要：目的探讨HER2、Ki-67、TK1蛋白与脑膜瘤恶性程度及复发的关系。方法选择良性复发脑膜瘤患者石蜡标本20例(良性复发组),另选同期非复发脑膜瘤60例患者石蜡标本按WHO分级标准分为:良性非复发组、非典型组及恶性组,每组各20例。采用免疫组织化学MaxVisionTM法对4组石蜡切片进行HER2、Ki-67、TK1蛋白的检测。结果良性非复发组、良性复发组、非典型组和恶性组脑膜瘤的HER2阳性率分别为15%、30%、35%和50%,随恶性程度增加,HER2蛋白表达增加(P<0.05);良性复发组HER2阳性率高于良性非复发组(P<0.05)。Ki-67和TK1的标记指数(LI)良性非复发组明显低于非典型组和恶性组(均P<0.05);非典型组低于恶性组(P<0.05);良性复发组高于良性非复发组(P<0.05)。且HER2与Ki-67、TK1均呈正相关(P=0.000,r=0.445和P=0.000,r=0.501);Ki-67与TK1呈正相关(P=0.000,r=0.450)。结论HER2联合Ki-67或TK1检测,可作为脑膜瘤病理形态学诊断的补充,为临床个体治疗提供参考。HER2阳性且Ki-67或TK1高水平表达提示脑膜瘤恶性程度较高及复发的可能性大。Objective To investigate the relativity of expression of HER2,Ki-67 and TK1 protein with the malignancy grade and recurrence of meningiomas. Methods According to the World Health Oranization （WHO） histological classification of nervous system and benign tumors whether relapse, twenty paraffin samples of recurrence benign meningiomas and sixty paraffin samples of non-recurrence meningiomas in the corresponding period were averagely divided into 4 groups： recurrence benign group, non-recurrence benign group, atypical group and malignant group. The expression of HER2,Ki-67 and TK1 protein were examined by immunohistochemical staining. Results The positive rate of HER2 expression in non-recurrence benign group, recurrence benign group, atypical group and malignant group were 15 %, 30 %, 35 %, 50%, respectively （P〈0.05） ,the higher grade malignancy,the higher rate of HER2 expression（P.Q0. 05） ,and the rate in recurrence group was higher than non-recurrence benign group（P〈0.05）. The labeling indexes（LI） of Ki-67 and TK1 in non-recurrence group were lower than those in atvoical or malignant group（P〈0.05）, and the LI in malignant group and recurrence benign group were higher than those in atpical group and non-recurrence benign group,respectively（P〈0.05）. Correlation analysis demonstrated that the expression of HER2 was positively correlated with Ki-67 and TK1, respectively（P=0. 000,r=O. 445;P=0. 000,r=0. 501） ,and there was a positive correlation between Ki-67 and TKI（P=0. 000,r=0. 450）. Conclusion Combined detection of HER2 with Ki-67 or TK1 can be used as a reference index for meningioma pathological diagnosis and individual cure. The positive HER2 with high level expression of Ki-67 or TK1 is closely related to high grade malignancy and recurrence of meningiomas.

关 键 词：脑膜瘤 复发 HER2 KI-67 TK1 

分 类 号：R739.41[医药卫生—肿瘤]