晚期乳腺癌患者化疗前后血清VEGF变化的临床意义  

Clinical significance of serum vascular endothelial growth factor change before and after chemotherapy in patients with advanced breast cancer

作　　者：李菊梅[1] 韩建军[1] 郭梅艳[1] 李静霞[1] 

机构地区：[1]河北工程大学附属医院乳腺科,河北邯郸056029

出　　处：《中国妇幼保健》2009年第20期2859-2860,共2页Maternal and Child Health Care of China

基　　金：邯郸市科学技术研究与发展计划项目〔20072817059-3〕

摘　　要：目的:通过测定乳腺癌患者化疗前、后血清中血管上皮生长因子(VEGF)的浓度变化,以期观察血清VEGF与乳腺癌患者化疗疗效之间的相关性。方法:采用酶联免疫吸附法(ELISA)分别检测60例乳腺癌患者化疗前、后血清VEGF水平,以20名正常健康志愿者血清VEGF水平作为对照。结果:乳腺癌组化疗前血清VEGF含量明显高于对照组(P<0.01),化疗后血清VEGF显著下降(P<0.01)。结论:连续检测血清VEGF的表达水平能在一定程度上帮助临床判断化疗近期疗效及监测肿瘤的进展。Objective： To detect the serum vascular endothelial growth factor （VEGF） change before and after chemotherapy in patients with advanced breast cancer, explore the correlation between serum VEGF and efficacy of chemotherapy. Methods： The levels of VEGF before and after chemotherapy in 60 cases with advanced breast cancer were detected by enzyme linked immunosorbent assay, the lev- els of VEGF in 20 healthy volunteers were considered as control group. Results ： The level of VEGF before chemotherapy in breast cancer group was significantly higher than that in control group （ P 〈0. 01 ）, the level of VEGF after chemotherapy reversed （ P 〈0. 01 ） . Conclusion： Continuous detection of serum VEGF can evaluate the short -term efficacy of chemotherapy and monitor the progress of tumors.

关 键 词：乳腺癌 VEGF 化疗 

分 类 号：R737.9[医药卫生—肿瘤]