前列腺癌中甾体激素受体共活化物表达研究  

AIB1 expression in prostate cancer

作　　者：黄翔[1] 邹建华[1] 廖勇[1] 龚百生[1] 

机构地区：[1]四川省医学科学院四川省人民医院泌尿外科,四川成都610072

出　　处：《西部医学》2009年第7期1139-1140,共2页Medical Journal of West China

摘　　要：目的探讨甾体激素受体共活化物(AIB1)在前列腺癌(Pca)中的表达及激素依赖性转变过程中的作用。方法采用SABC免疫组化法检测40例前列腺癌症患者中AIB1蛋白在BPH、ADPC及AIPC石蜡切片组织中的表达,应用ImagePro Plus 4.5图象分析软件测定阳性染色积分光密度(IOD)值。结果AIB1阳性表达定位于细胞核和/或细胞质中。在8例BPH、20例ADPC和12例AIPC标本中AIB1均有表达,但各组IOD值无统计学差异(P>0.05)。结论AIB1不是决定前列腺癌生物学行为和激素依赖性的关键因素。Objective To investigate the expression of AIB1 in prostate cancer and explore the role of AIB1 in regulating the variation of AR-dependence of prostate cancer. Methods AIB1 expression was examined by immunohistochemical assay. The IOD value was canculated by ImagePro Plus 4.5 analysis software. Results AIB1 protein locolized in plasma and/or nuclear. There was no statistical deference of IOD value between each group （P〉0. 05）. Conclusion AIB1 is not a crutial factor determining the biological characteristics and AR dependence of prostate cancer.

关 键 词：前列腺癌 AIB1 免疫组化 

分 类 号：R737[医药卫生—肿瘤]