壳聚糖在胰岛素口服给药中的作用  

Investigating the role of Chitosan in the oral insulin preparations

作　　者：李建波[1] 王玮[1] 凌春生[1] 景恒翠[1] 靳蓉[1] 

机构地区：[1]河南大学药学院药剂教研室,河南开封475004

出　　处：《河南大学学报（医学版）》2009年第2期118-120,共3页Journal of Henan University:Medical Science

摘　　要：目的:研究壳聚糖在胰岛素口服给药中的作用。方法:以降糖百分数为指标,考察胰岛素溶液、壳聚糖溶液、壳聚糖-胰岛素混合液经正常大鼠口腔给药后对血糖的影响。结果:壳聚糖-胰岛素溶液的降血糖作用与胰岛素溶液相比有显著性差异(P=0.001),而与壳聚糖溶液相比无显著性差异(P=0.069)。结论:壳聚糖具有一定的降血糖作用,并且它的特殊结构还对胰岛素起到了保护和促进吸收的作用,是一种优良的胰岛素口服制剂的载体。Objective： To investigate the role of Chitosan in the oral insulin preparations. Methods： We investigated the hypoglycemic effect after oral administration of Chitosan, insulin solution, Chitosan insulin mixture to the normal rats by blood glucose changes. Results： Compared with the function of the insulin solution, the Chitosan insulin is markedly different, rnoreover, it has no difference with the Chitosan solution. Conclusion： Chitosan itself has some hypoglycemic effect, and the special structure of the Chitosan can be also served to protect and promote the role of absorption of insulin, it is a good carrier of oral insulin preparations.

关 键 词：胰岛素 壳聚糖 口腔给药 降血糖作用 

分 类 号：R943[医药卫生—药剂学]