30例重症肌无力患者人类白细胞抗原-Ⅱ基因多态性测定及分析  

Determination and analysis of HLA-Ⅱ gene polymorphism in 30 cases with MG

作　　者：张艺凡[1] 楚兰[1] 徐竹[1] 蔡立君[1] 

机构地区：[1]贵阳医学院附属医院,贵阳550004

出　　处：《山东医药》2009年第23期36-37,共2页Shandong Medical Journal

摘　　要：目的探讨人类白细胞抗原(HLA)-Ⅱ基因多态性在贵州汉族人群重症肌无力(MG)发病中的作用。方法选择本地区汉族人群中30例MG患者(MG组)、36例神经内科非自身免疫性疾病患者(疾病对照组)及30例健康查体者(正常对照组),采用PCR-序列特异性引物(PCR-SSP)技术进行HLA-Ⅱ类基因DRB1、DQB1位点分型,并对其与MG的相关性进行分析。结果MG组HLA-DRB1*0901和DQB1*0303等位基因频率显著高于其他两组(P<0.05),DQB1*0601等位基因频率显著低于其他两组(P<0.05)。结论HLA-DRB1*0901及DQB1*0303可能为MG的易感基因,而HLA-DQ*0601为保护基因。Objective To investigate the effects of HLA- Ⅱ gene polymorphism in the pathogenesis of MG in Guizhou Hans. Methods 30 cases with MG （MG group）, 36 NO-MG patients （disease control group） and 30 healthy controls （normal control group）were selected ,the DRB1, DQB1 genotype of HLA alleles were detected by PCR-SSP, and its relationship with MG was analyzed. Results Frequency of HLA-DRB1 ＊ 0901 and DQB1 ＊ 0303 alleles in MG group were significantly higher than that in the other two groups , and the frequency of DQB1 ＊ 0601 was significantly lower than that in the other two groups. Conclusion DRB1＊0901 and DQB1 ＊ 0303 are susceptible genes, DQB1 ＊ 0601 is protective genes to MG in Guizhou Hans.

关 键 词：重症肌无力 HLA 基因型 

分 类 号：R746.1[医药卫生—神经病学与精神病学]