14例茄病镰刀菌所致角膜溃疡临床分析  

Fourteen cases of corneal ulcer induced by Fusarium solani

作　　者：冯广忠[1] 李鹤玉[2] 盛宇[2] 刘会彬[2] 郑淑云[2] 

机构地区：[1]哈尔滨医科大学第一临床医学院眼科,哈尔滨150001 [2]哈尔滨医科大学第一临床医学院皮肤科,哈尔滨150001

出　　处：《中国真菌学杂志》2009年第3期144-147,共4页Chinese Journal of Mycology

摘　　要：目的探讨真菌性角膜溃疡的病原学特点、临床表现及抗真菌综合治疗的方法。方法对2004年10月～2006年10月送检的疑似感染的角膜标本进行镜检、培养及菌种鉴定。对其中14例病历资料完整的茄病镰刀菌所致角膜溃疡患者进行临床分析。结果在33例送检标本中分离出茄病镰刀菌24株(72.7%)。上述14例患者中,有3例角膜穿孔合并眼内炎行眼球内容物除去术,3例行结膜瓣或羊膜移植,1例角膜移植,7例经非手术治疗保留较好视力。结论茄病镰刀菌是我国北方真菌性角膜炎的主要致病菌,可导致视力严重受损且治愈困难。早期诊断配合以抗真菌为主的综合治疗可阻止病情进展,明显改善视力。Objective To investigate the etiologic feature, clinical manifestations and antifungal treatment of fungal corneal ulcer. Methods Microscopic examination, cultivation, isolation and identification were performed on cornea with suspected infection from October 2004 to October 2006, in which 14 cases with complete clinical data of corneal ulcer induced by Fusarium solani were analyzed. Results Twenty-four strains （72.7%） ofFusarium solani were identified from 33 specimens. Within the 14 patients, 3 cases of perforatio cornea combined with endophthalmitis were dealt with ophthalmectomy, 3 cases were dealt with conjunctival flap or amniotic membrane grafting, 1 case received corneal transplantation, 7 cases with non-operative treatment remained good eyesight. Conclusions Fusarium solani is the predominant pathogen of the fungal keratitis in northern China. The disease can lead to severe vision damage which is difficult to be cured. Early diagnosis and combined therapy with antifungal drugs could prevent the exacerbation of fungal keratitis with improved eye sight.

关 键 词：真菌性角膜炎 镰刀菌属 综合治疗 

分 类 号：R772.21[医药卫生—眼科]