磁共振成像以线性、面积、体积、容积评估阿尔茨海默病的结构影像学特点  

Imaging features of Alzheimer's disease using magnetic resonance imaging in linearity,area and volume

作　　者：袁强[1] 陈芹[1] 周东[1] 

机构地区：[1]四川大学华西医院神经内科,四川省成都市610041

出　　处：《中国组织工程研究与临床康复》2009年第26期5117-5121,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目(30770749)~~

摘　　要：近年来磁共振成像技术在阿尔茨海默病相关研究中的应用发展迅速。磁共振成像结构影像学主要介绍了磁共振成像线性和面积测量、磁共振成像体积测量和磁共振容积再现三方面,其研究热点主要集中于阿尔茨海默病患者异常脑结构的分布,以及特征性结构内侧颞叶,尤其是海马,杏仁核,以及内嗅皮质在结构在阿尔茨海默病早期诊断治疗中的作用。磁共振成像功能影像学主要包括了功能磁共振成像、扩散加权成像及扩散张量成像等新技术在阿尔茨海默病患者早期脑功能改变中的应用。随着这些研究的进展突破,磁共振成像影像技术将有助于进一步深入了解阿尔茨海默病的发病机制及生物学特征。Magnetic resonance imaging has shown its important role in both early diagnosis of Alzheimer＇s disease and revealing the AIzheimer＇s disease pathogenesis. Structural magnetic resonance imaging include lineal mesure, volume measure and volume rendered. They can detect the abnormal brain structure, especially the change of mesial temporal lobe （hippocampus, amygdale） in early onset of Alzheimer＇s disease. Recent studies more focused on functional imaging which can find the functional changes in brain. Prior to structural changes, functional changes happen, so it can reflect the sutile pathological process in Alzheimer＇s disease. The functional imaging mainly refers to magnetic resonance spectroscopy, functional magnetic resonance imaging, diffusion weighted imaging and diffusion tensor imaging. As developing of these new technologies, we know more and more about pathogenesis and biological characteristics of Alzheimer＇s disease.

关 键 词：磁共振成像 结构影像学 功能影像学 阿尔茨海默病 

分 类 号：R742.5[医药卫生—神经病学与精神病学]