多发性骨髓瘤患者BAG-1和BCL-2在骨髓活检组织的表达  

BAG-1 and BCL-2 expression in tissues of multiple myeloma

作　　者：黄来全[1] 张岱云[1] 张军[1] 汪兴洪[1] 

机构地区：[1]皖南医学院附属弋矶山医院血液内科,安徽芜湖241001

出　　处：《皖南医学院学报》2009年第4期242-245,共4页Journal of Wannan Medical College

基　　金：安徽省卫生厅自筹项目(2008B045)

摘　　要：目的:通过观察BCL-2结合抗凋亡基因1(BAG-1)和BCL-2在多发性骨髓瘤(MM)患者骨髓活检塑料包埋切片中的表达,探讨MM的发病机制和预后。方法:用SP免疫组化法检测MM患者骨髓活检组织塑料包埋切片中BAG-1和BCL-2的表达。结果:BAG-1和BCL-2在MM组中高表达,在对照组中低表达,P<0.05差异具有统计学意义;与BAG-1和BCL-2低表达患者相比,高表达BAG-1和BCL-2的患者骨损害明显,白蛋白低,β2微球蛋白高。结论:BAG-1和BCL-2在MM发病中具有促进作用,BAG-1可能参与MM的发生,提示预后不良。Objective： To investigate the pathogenesis and prognosis of muhiple myeloma（MM） by observing the expression of BAG-1 and BCL-2 in the myeloid tissues. Methods：Immunohistochemical method（Streptavidin-Peroxidase） was used to detect the expression levels of BAG-1 and BCL-2 from the bone marrow with plastic embedding. Results ： Highly expressed BAG-1 and BCL-2 were found in cases with MM ,but that was low in the controls （P 〈 0. 05 ）. Those cases with high expression level of BAG-1 and BCL-2 were found with evident bone impairment,low level of albumin but high 132 microglobulin in comparison with the cases of lower expression. Conclusion：BAG-1 and BCL-2 protein may result in the development of MM and the presence of BAG-1 can predicate the poor outcome of this disease.

关 键 词：BAG-1 BCL-2 多发性骨髓瘤 免疫组化 

分 类 号：R733.3[医药卫生—肿瘤]