伊立替康联合卡培他滨与5-Fu/CF治疗晚期胃癌的临床观察  

Comparative study of drug combination of CPT-11 plus CAP and 5-Fu/CF in the treatment of advanced gastric cancer

作　　者：杨茂鹏[1] 王艳[1] 赵红丽[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内五科,150040

出　　处：《齐齐哈尔医学院学报》2009年第10期1162-1164,共3页Journal of Qiqihar Medical University

摘　　要：目的研究伊立替康联合CAP和5-Fu/CF方案治疗晚期胃癌的近期疗效和毒副反应。方法经病理组织学诊断的晚期胃癌77例随机分成两组,实验组39例,用CPT-11100mg/m2,静脉滴注90min,d1,d8;CAP1000mg/m2,2次/天,d1-14口服;对照组38例,给予5-Fu400mg/m2,d1,d2,静脉滴入,5-Fu600mg/m2,微量泵泵入48h以上。21天为一个周期,治疗2个周期后评定疗效。结果实验组39例总有效率为48.7%(19例),对照组38例总有效率为21.1%(8例),差异有统计学意义(P<0.025)。主要毒副反应为迟发性腹泻,而血液学毒性、消化道副反应及肝肾毒性、脱发等相对轻微,无治疗相关性死亡患者。结论CPT-11联合CAP治疗晚期胃癌疗效明显优于5-Fu/CF,值得临床推广使用。Objective To compare the recently curative,noxious and side effects of drug combination of CPT-11 plus CAP and 5--FU/CF in the treatment of advanced gastric cancer. Methods 77 cases of advanced gastric cancer diagnosed by pathology and histology were divided into 2 groups randomly. Experimental group（39 cases）： CPT--11 100 mg/m^2 was injected in 90 minutes in d1,8 ,capecitahine 1000 mg/m^2 was taken twice a day in d1-14. Control group（38 cases） ： CF 200 mg was injected in dl, 2, followed by the injection of 5-Fu 400 mg/m^2 in d1, 2 and the micro pumping of 5-Fu 600 mg/m2 over 48 hours in d2. The treatment was repeated every three weeks as one cycle and the treatment effect was evaluated after 2 cycles. Results The total effective rates of experimental group （39 cases） and control group（38 cases） are 48.7% （19cases） and 21.1% （8 cases） , respectively . There was statistical significance between the two groups （P 〈 0.025）. The main noxious and side effects were delayed diarrhea,leucopenia,nausea and vomiting,etc. There was no treatment related death. Conclusions The curative effect of drug combination of CPT--11 plus CAP is superior to 5-Fu/CF in the treatment of advanced gastric cancer and the combination is recommended to he used widely.

关 键 词：伊立替康 卡培他滨 5-FU 晚期胃癌 

分 类 号：R735.34[医药卫生—肿瘤] R735.2[医药卫生—临床医学]