TK1、Ki-67在大肠癌发生发展中作用及其相关性  

The roles and their correlation of TK1 and Ki-67 in the pathogenesis of colorectal carcinoma:a tissue microarrays study

作　　者：吴鸿雁[1] 樊祥山[1] 孟凡青[1] 余慧萍[1] 周强[1] 

机构地区：[1]南京大学医学院附属鼓楼医院病理科,南京210008

出　　处：《临床与实验病理学杂志》2009年第3期282-286,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：南京市科技发展计划项目(200601050)

摘　　要：目的研究TK1在大肠癌发生发展过程中的作用,并探讨与Ki-67的相关性。方法应用组织芯片技术和免疫组织化学方法检测120例大肠癌(无淋巴结转移44例,有淋巴结转移76例)、19例大肠腺瘤以及11例正常大肠黏膜中TK1和Ki-67的表达情况,并分析二者在大肠癌发生过程中的作用以及其与大肠癌患者各临床病理学参数之间的关系。结果TK1和Ki-67在大肠正常黏膜组织、腺瘤以及腺癌三组中的表达强度均具有明显差异(分别为χ2=55.096,P=0.000;χ2=53.047,P=0.000),并与大肠癌的恶性演变过程呈明显正相关性(rs=0.462,P=0.000;rs=0.487,P=0.000)。在大肠癌组,二者的表达与患者年龄、性别、组织学分级、肿瘤浸润程度、淋巴结转移以及病理分期之间均无显著相关性,但二者之间却呈显著正相关(rs=0.753,P=0.000)。结论TK1可能参与大肠癌的发生,但与大肠癌的进展无关。Purpose To investigate the expression of TK1 and its relationship with Ki-67 in colorectal carcinoma. Methods TK1 and Ki-67 expressions in 120 cases of colorectal cancer （76 cases with lymph node metastases, and 44 cases without）, 19 cases of adenoma and 11 cases of normal intestinal mucosa were detected by tissue microarrays and immunohistochemical method. The relationship between expression status of two makers and colorectal cancer＇s clinicopathological parameters were evaluated. Results The expression intensity of TK1 and Ki-67 was significantly higher in adenocarcinoma group than that in adenoma and normal tissue groups （χ^2= 55. 096,P =0. 000;χ^2 = 53. 047, P = 0. 000）, and both of them were positively related with the carcinogenesis of colorectum（ rs = 0. 462, P = 0. 000 ; rs = 0. 487, P = 0. 000 ）. In the group of colorectal carcinoma, both TK1 and Ki-67 expression was no significant correlated with age, sex, grade, tumor invasion, lymph node metastasis and TNM stage, there was a positive correlation between the expression of TK1 and Ki-67 （ rs = 0. 753, P = 0. 000）. Conclusions TK1 may play an important role in the pathogenesis processes of colorectal cancer, but not in the development of them.

关 键 词：结直肠肿瘤 TK1 KI-67 

分 类 号：R735.3[医药卫生—肿瘤]