观察葡萄糖酸钙对草酸铂所致周围神经毒性的预防作用  

Prevention of oxaliplatin - induced neuropathy by Ca gluconate in patients with advanced colorectal cancer

作　　者：王丽[1] 张利民[1] 张春民[1] 

机构地区：[1]山东省潍坊市寒亭区人民医院,261100

出　　处：《中国实用医刊》2009年第14期8-9,共2页Chinese Journal of Practical Medicine

摘　　要：目的 观察葡萄糖酸钙对草酸铂（L—OHP）引起的神经毒性的预防作用。方法59例患者随机分为两组，研究组为葡萄糖酸钙＋化疗（改良FOLFOX4）；对照组为单用化疗（改良FOLFOX4）。研究组在静脉滴注L—OHP前后加用10％葡萄糖酸钙10ml缓慢静脉推注。结果神经毒性发病率研究组为36．7％，对照组为55．2％，两组比较差异有统计学意义（P〈0．05）。L—OHP平均累积剂量两组间比较差异无统计学意义（P〉0．05）。结论葡萄糖酸钙可以有效减少L—OHP神经毒性的发生率。Objective To assess the neuroprotectant effect of Ca gluconate against oxaliplatin - induced neurotoxicity. Methods Fifty - nine patients were divided into two guoups randomly. Experimental group received chemotherapy and Ca gluconate, and control group only received chemotherapy. The infusion of Ca gluconate （ 1g） was proceeded before and after oxaliplatin. Results Of all patients available, the incidences of neurotoxieity in experimental group and control group were 36.7%, 55.2% respectively （ P 〈 0. 05 ）. No difference of L - OHP cumulative dose was ovserved between the two groups （P 〉 0.05 ）. Conclusions The infusion of Ca glueonate can reduce the incidence of oxaliplatin - induced neurotoxicity effectively..

关 键 词：葡萄糖酸钙 草酸铂 神经毒性 预防 

分 类 号：R730[医药卫生—肿瘤]