Cyr61和VEGF在慢性髓细胞白血病中的表达及相关性探讨  

Expressions of Cyr61 and VEGF in human chronic myeloid leukemia and their associativity

作　　者：王志敏[1] 丛雅琴[1] 马立宁[1] 胡晓静[1] 阎树昕[1] 林庆国[2] 

机构地区：[1]山东大学齐鲁医院肿瘤防治中心,济南250012 [2]山东中医药大学管理系

出　　处：《临床血液学杂志》2009年第4期354-356,共3页Journal of Clinical Hematology

摘　　要：目的:探讨富半胱氨酸61(Cyr61)基因蛋白在慢性髓细胞白血病(CML)中的表达及其与血管内皮细胞生长因子(VEGF)基因表达的相关性。方法:应用免疫组织化学SP法检测40例CML患者及10例正常对照组骨髓单个核细胞中Cyr61、VEGF蛋白的表达,分析其与CML的发生、发展的关系及2者的相关性。结果:①CML患者在慢性期、加速期、急变期骨髓单个核细胞中Cyr61和VEGF蛋白表达水平明显高于正常对照组(P<0.05)。Cyr61和VEGF蛋白在加速期和急变期的表达明显高于慢性期(P<0.05);②CML中染色体核型异常组Cyr61和VEGF表达显著高于无染色体核型异常组(P<0.05);③治疗后达完全缓解(CR)组Cyr61和VEGF蛋白表达低于未缓解组(NR);④Cyr61和VEGF蛋白在CML中的表达呈显著正相关(r=0.896 2,P<0.01)。结论:Cyr61和VEGF基因蛋白在CML中的异常表达可能与CML的发生、发展及预后有关,且2者存在一定的相关性。Objective：To explore the expressions of cysteine rich 61（Cyr61） and VEGF protein and their correlation in human chronic myeloid leukemia （CML）. Method： Expressions of Cyr61 and VEGF protein were detected in bone marrow mononuclear cell （BMMNC） from 40 patients with CML and 10 normal controls by immunohistochemical method. Result： （1）Expressions of Cyr61 and VEGF protein in chronic phase, accelerated phase and blast crisis were significantly higher in CML patients than in normal controls （P〈0.05）. Expressions of Cyr61 and VEGF protein were higher in accelerated phase and blast crisis than in chronic phase （P〈0.05）. （2） Expressions of Cyr61 and VEGF protein in BMMNC were higher in CML patients with abnormal karyotype than in CML patients without abnormal karyotype （P〈0.05）. （3）Expressions of Cyr61 and VEGF protein in BMMNC were lower in patients who reached CR than in patients who failed （P〈0.05）. （4）Expressions of Cyr61 and VEGF protein in CML patients were significantly associated （r= 0. 896 2, P〈0. 01）. Conclusion： Overexpressions of Cyr61 and VEGF protein may be related to the progression, genesis and prognosis of CML patients.

关 键 词：白血病 慢性 髓细胞性 富含半胱氨酸61 血管内皮细胞生长因子 

分 类 号：R733.72[医药卫生—肿瘤]