我国部分省市区鼠伤寒沙门菌的质粒谱分型及其分布  

Plasmid Profile Typing of Salmonella Typhimurium and Its Distribution in Some Provinces and Cities of China

作　　者：潘若男[1,2,3,4,5] 魏旭兰[1,2,3,4,5] 罗明 何晓青[1,2,3,4,5] 侯惠珍 周刚 谢一俊[1,2,3,4,5] 

机构地区：[1]南昌市医学科学研究所 [2]江西省卫生防疫站 [3]新疆维吾尔自治区卫生防疫站 [4]河南省卫生防疫站 [5]福建省卫生防疫站

出　　处：《中华预防医学杂志》1998年第4期214-218,共5页Chinese Journal of Preventive Medicine

摘　　要：目的探明各省市间鼠伤寒沙门菌感染流行之间的关系。方法１９８０～１９９５年鼠伤寒沙门菌感染在我国北方和南方流行期间，自１９个省、自治区、直辖市和香港特别行政区收集鼠伤寒沙门菌２６５５株做质粒谱分析。将质粒图谱编码，小质粒带组成的图形分别用大写字母编码为Ａ～Ｊ，没有小质粒的编码为Ｏ；并按大质粒分子量１４０～２０Ｍｄ依次从９编码到０；两个及两个以上大质粒用两位或两位以上数字表示。结果２６５５株鼠伤寒沙门菌可分为１１个类群，１６８个质粒谱型，常见的质粒谱型有５２个。Ｏ４质粒谱型在１６个省市区和香港广泛分布；Ｏ５质粒谱型在５个省和香港分离到，以江西和湖北最多；Ｊ４质粒谱型在７个省市区分离到，以江西最多；Ａ类群的５个质粒谱型在河南引起医院内感染的大流行；Ａ６质粒谱型还在新疆和安徽分离到；Ｅ类群６个质粒谱型主要在新疆流行；３个质粒谱型在上海引起医院内感染；Ｅ８２质粒谱型在辽宁引起医院内感染和食物中毒；Ｆ４质粒谱型在４个省分离到，以江西和福建多。此外还有一些地区性流行的质粒谱型。结论同一起爆发中菌株质粒谱型相同；Objective To study the relationship between the infection and prevalence of Salmonella typhimurium. Methods From 1980 to 1995, when Salmonella typhimurium infection was prevalent in north and south China, a total of 2 655 isolates of Salmonella typhimurium were collected from 19 provinces, municipalities, and autonomous regions and Hong Kong Special Administrative Region for plasmid profile analysis. The profiles consisting of some small plamids were recorded with capital letters A to J, and the profile which was free from small plasmid was recorded with capital letter O. Large plasmid in molecular weights of 14020 Mdal showing in profiles was recorded with Arabic numerals 9 to 0 respectively. Having two or more than two large plasmids, the profile was recorded with two or more Arabic numerals. Results The 2 655 strains were divided into 11 plasmid profile groups and 168 plasmid profile types. Of 52 plasmid profile types frequently isolated, plasmid profile type O 4 was distributed extensively in 16 provinces, municipalities, and autonomous rehions and Hong Kong. Plasmid profile type O 5 was isolated in 5 provinces and Hong Kong, mostly in Jiangxi and Hubei. Plasmid profile type J 4 was isolated in 7 provinces, municipalities and autonomous regions, mostly in Jiangxi. Five plasmid profile types of Group A caused a big prevalence of nosocomial infection in Henan. Type A 6 was also isolated in Xinjiang and Anhui. Six plasmid profile types of Group E were prevalent in Xinjiang predominantely, three types caused nosocomial infection in Shanghai, type E 82 caused nosocomial infection and food poisoning in Liaoning. Type F 4 was isolated in 4 provinces, mostly in jiangxi and Fujian. Many plasmid profile types were prevalent local. Types B 5, BCEG 60, BE 6, B' 0 G 6, G 5 and EG 6 were prevalent in Jiangxi, Types IF'4, IF'H40 and F 9864 were prevalent in Sandong, Type IF'4 was also isolated in Jiangsu and Hubei, Type IF 40 in Anhui, Type BH 6 in Huibei, and Type EH 5 in Fujian. Conclusion Plasmi

关 键 词：沙门氏菌 鼠伤寒 质粒谱 伤寒 

分 类 号：R378.23[医药卫生—病原生物学] R516.3[医药卫生—基础医学]