2005-2007年太原市部分狂犬病疫苗接种者狂犬病病毒抗体检测结果分析  

Detection of rabies antibody among persons vaccinated with rabies vaccine in Taiyuan,2005-2007

作　　者：王骥涛[1,2] 石洁平 张晓林[2] 张拉弟[2] 孙樯[2] 韩建荣[1] 

机构地区：[1]山西大学生命科学与技术学院,山西太原030001 [2]太原市疾病预防控制中心,太原030013

出　　处：《疾病监测》2009年第6期396-397,共2页Disease Surveillance

摘　　要：目的了解接种狂犬病疫苗免疫后抗体水平,及时发现免疫失败的接种者,采取积极有效的补种措施,保证每位接种者得到有效的免疫。方法采用间接免疫荧光法(IFAT)测定狂犬病暴露者免疫后抗体效价,数据采用Excel、SPSS11.5软件进行处理。结果229例狂犬病疫苗接种者中狂犬病病毒抗体阳性者175例,阳性率为76.4%,阳性率在性别和年龄组之间差异无统计学意义,在疫苗来源和接种地方面差异有统计学意义。结论狂犬病疫苗进入人体后所引发的免疫反应并不由于性别、年龄而有所差别,建议被犬、猫等动物致伤后,尽可能到具有疫苗流通和接种资质的卫生服务部门接种。Objective To investigate the antibody level after vaccination of rabies vaccine ,and find the subjects who failed in the rabies immunization in a timely manner so that aggressive and effective revaccination could be taken to ensure effective immunization for each vaccination receiver. Methods The indirect immunofluorescence assay test （IFAT） was performed to detect rabies antibody of the subjects immunized after exposure. The data were processed using Excel and SPSS 11.5 software. Results A total of 175 rabies antibody-positive subjects were identified out of 229 vaccination receivers, the positive rate being 76.4%. There was no statistical difference in positive rates of rabies antibody by gender and age, but the statistical significant differences were observed on the sources of vaccine and the location of inoculation. Conclusion The immune response to rabies vaccine might not differed by gender or age. So it is highly suggested for people bitten by dogs, cats and other animals to be vaccinated in an available health service center with qualified vaccination.

关 键 词：狂犬病 接种疫苗 抗体 

分 类 号：R186[医药卫生—流行病学] R446.6[医药卫生—公共卫生与预防医学]