卵磷脂-肝素/蒙脱土纳米中间体的制备及血液相容性的研究  

Synthesis and hemocompatibility of phosphatidylcholine-heparin/montmorillonite nanocomposites

作　　者：高孝俊[1] 周宁琳[1,2,3] 方苏[1] 徐东[1] 章峻[1,2,3] 莫宏[1,2,3] 沈健[1,2,3] 

机构地区：[1]南京师范大学江苏省生物医药功能材料工程研究中心,江苏南京210097 [2]南京师范大学江苏省生物功能材料重点实验室,江苏南京210097 [3]南京大学江苏省表面与界面工程技术研究中心,江苏南京210093

出　　处：《功能材料》2009年第7期1181-1183,共3页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(20874047);国家高技术研究发展计划(863计划)资助项目(2006AA032Z445);教育部博士点基金资助项目(20050319010);江苏省教育厅基金资助项目(JHB05-21)

摘　　要：把具有良好抗凝血性能的卵磷脂-肝素(PC-hep)复合物插层进入蒙脱土(MMT)中,制备出一系列新型的PC-hep/MMT纳米中间体。通过XRD对纳米中间体的结构和性能进行了表征;在此基础上,用复钙化时间曲线和溶血试验表征了纳米中间体的血液相容性,可以看出当随着材料的浓度增加,复钙时间曲线由陡峭趋于平滑;同时材料的溶血率都低于5%说明材料有很好的血液相容性,因此可以作为生物材料用于医用领域。In the paper,a novel compound of phosphatidylcholine-heparin （PC-hep）with favorable anticoagulant was intercalated in montmorillonite （MMT）. The structure and properties of the compound were characterized by X-ray diffraction（XRD）. The blood compatibility of the composites were evaluated by curve of recalcification time and hemolysis test. The resurts show that reealcification time by the steep curve tends to smooth with the increase in the concentration of material. It was observed that hemolysis was less than 5% in all the cases,which comes well within permissible limit. Hence, it may be conclude that the synthesized PC- hep/MMT nanocomposites may be suitable as biomaterials in the field of medical.

关 键 词：蒙脱土 卵磷脂 肝素 抗凝血 

分 类 号：TB39[一般工业技术—材料科学与工程]