阿尔茨海默病的免疫治疗研究新进展  

New advances in immunotherapy for Alzheimer＇ s disease

作　　者：孙兆霞[1] 马春[1] 

机构地区：[1]山东万杰医学院解剖教研室,淄博255213

出　　处：《国际免疫学杂志》2009年第4期304-307,共4页International Journal of Immunology

摘　　要：阿尔茨海默病（AD）是痴呆最常见的原因。根据淀粉样蛋白级联假说，AD的疫苗治疗成为该病的治疗方法。虽然AD的主动免疫治疗的Ⅱ期临床试验由于一些病人出现了脑膜脑炎而停止，但被治疗病人的临床和病理研究都表明疫苗治疗是有效的。为了避免AB疫苗诱发的脑膜脑炎，研究者试偿了各种各样的方法，其中包括发展短的免疫原、使用新的佐剂、改变给药途径、研制DNA非病毒载体的疫苗和应用催化性抗体。一些在转基因小鼠上的实验研究表明，上述的方法是AD的安全有效的治疗方法。Alzheimer＇ s disease（AD） is the most common cause of dementia. Based on the amyloid cascade hypothesis, vaccine therapy for AD was developed as a curative treatmant. Although the clinical trials of active vaccination for AD patients were halted due to the development of meningoencephalitis in some patients, analysis of the clinical and pathological findings of treated patients, shaved that vaccine therapy was effective. To avoid the possible meningoencephalitis resulting from Aβ vaccination, various strategies have been attempted ineluding developing shorter immunogens, using new adjuvant, modifying administin ways, developing non-viral DNA vaccine, and using catalytic antibodies to Aβ. Experimental studies in transgenic mouse models of AD have demonstrated that the strategies mentioned above are safe and effective for the treatment of AD.

关 键 词：Alzheimer’s病 免疫治疗 阿尔茨海默病 痴呆 

分 类 号：R749.16[医药卫生—神经病学与精神病学]