穿通支原体感染与胃癌和结直肠癌组织分化以及浸润转移的关系  

Correlations of Mycoplasma penetrans infection with the differentiation, invasiveness and metastasis of stomach and colorectai carcinomas

作　　者：温秀姝[1] 王伟华[1] 周丽萍[1] 周素梅[1] 蓝升红[1] 曾云祥[1] 

机构地区：[1]温州医学院附属第一医院检验科,325000

出　　处：《中华临床感染病杂志》2009年第1期39-42,共4页Chinese Journal of Clinical Infectious Diseases

摘　　要：目的 探讨穿通支原体（MPe）感染与胃癌和结直肠癌组织分化及浸润转移的关系。方法对122例胃肠癌患者（65例胃癌，57例结直肠癌）与80名对照者分别进行MPe分离鉴定和PCR核实。MPe检出结果与组织分化和浸润转移之间关系的比较分析采用x^2检验。结果胃癌组MPe检出率（41／65，63．1％）与胃溃疡组（1／20，5％）比较差异有统计学意义（x^2=38．2，P〈0．01）；结直肠癌组MPe检出率（33／57，57．9％）与结直肠息肉组（1／20，5％）比较差异有统计学意义（X^2=21．2，P〈0．01）；MPe阳性胃癌组低分化检出率以及浸润程度与MPe阴性组比较差异均有统计学意义（，值分别为33．4和25．0，P值均〈0．01）；MPe阳性结直肠癌组低分化检出率以及第三站淋巴转移率与MPe阴性组比较差异有统计学意义（X^2=34．4，P〈0．01）。结论胃癌和结直肠癌的组织分化、浸润及转移与MPe感染密切相关。Objective To investigate the correlations ofMycoplasmapenetrans （MPe） infection with the differentiation, invasiveness and metastasis of stomach and colorectal carcinomas. Methods Sixty five patients with stomach carcinoma, 57 patients with colorectal carcinoma and 80 healthy individuals as controls were enrolled in this study. MPe was isolated and then confirmed by PCR. X^2 test was performed to analyze the correlations of MPe infection with the differentiation, invasiveness and metastasis of carcinoma. Results The rate of MPe isolated from stomach carcinoma group （41/65, 63.1% ） was significantly higher than that from stomach ulcer group （X^2 = 38.2, P 〈 0.01 ）. The rate of MPe isolated from colorectal carcinoma group （1/20, 5% ） was also significantly higher than that from colorectal polyps group （X^2 = 21.2, P 〈0.01 ）. The proportion of poor differentiation and the invasiveness in MPe positive stomach carcinoma group were significantly higher than those in MPe negative group （X^2 = 33.4 and 25.0, P 〈0.01 ）. The proportion of poorly differentiation and lymphatic metastasis （N3） in MPe positive colorectal carcinoma group were significantly higher than those in MPe negative group （X^2 = 34.4, P 〈 0.01 ）. Conclusion Differentiation, invasiveness and metastasis are highly correlated with MPe infection in stomach and colorectal carcinomas.

关 键 词：支原体 穿通 胃癌 结直肠癌 浸润 转移 

分 类 号：R735[医药卫生—肿瘤]