青岛地区乙型肝炎病毒基因型分布及其与肝细胞癌的相关性  

Distribution of hepatitis B virus genotypes in Qingdao and the correlation between its and hepatocellular carcinoma

作　　者：王义成[1] 李建忠[1] 

机构地区：[1]青岛市传染病医院,青岛266033

出　　处：《中国医疗前沿》2009年第9期136-137,共2页China Healthcare Innovation

摘　　要：目的了解青岛地区乙型肝炎病毒(HBV)基因型分布特征,探讨其与肝细胞癌的相关性。方法选取HBVDNA阳性患者共112例,其中慢性乙型肝炎(CHB)患者40例、肝硬化(LC)患者38例、肝细胞癌(HCC)患者34例,应用荧光PCR(探针)法检测HBV基因型。结果112例患者中,HBV基因型B型1例(0.9%),C型95例(84.8%),非B非C型16例(14.3%),HBV基因型B型、C型的分布频率在3组之间的差异均无统计学意义(P值均>0.05)。结论青岛地区HBV基因型以C型为主,未发现HBV基因型B型、C型与肝细胞癌的发生存在相关性。Objective To investigate the distribution of hepatitis B virus（HBV） genotypes in Qingdao, and to explore the correlation between HBV genotype and hepatocellular carcinoma. Methods Experiment groups were composed of 40 patients with chronic hepatitis B, 38 patients with liver cirrhosis and 34 patients with hepatocellular carcinoma. Hepatitis B virus genotypes were typed by real time PCR（Taqman probe）. Results Of the 112 patients, 1（0.9%） was genotype B, 95 （84.8%） were genotype C, and 16（14.3%） were genotype BC. The distribution of HBV genotype B, C had no significant difference among the three groups（P 〉 0.05）. Conclusions HBV genotype C is the major genotype in Qingdao. No correlation was found between HBV genotype B, C and hepatocellular carcinoma.

关 键 词：HBV基因型 肝细胞癌 青岛 荧光PCR 

分 类 号：R735.7[医药卫生—肿瘤]