鸦胆子在体部伽玛刀治疗老年非小细胞肺癌中的药效价值  

作　　者：叶斌[1] 董桂云 虞喜豪 肖作平 

机构地区：[1]上海应用技术学院,200032 [2]解放军八五医院伽玛刀病房

出　　处：《当代医学》2009年第21期140-141,共2页Contemporary Medicine

摘　　要：观察鸦胆子联合体部伽玛刀治疗老年非小细胞肺癌的近期疗效及毒副反应,经临床、影像学和病理学诊断160例非小细胞肺癌,采用随机分组原则分为鸦胆子加体部伽玛刀治疗组和单纯体部伽玛刀治疗组。结果表明,按照RECIST标准评价近期疗效,参照Karnofsky评分(KPS)变化评价生活质量。2周期后评价疗效。主要终点指标为疾病进展时间(TTP),和总生存期(OS),次要终点为客观有效率(RR),生活质量,和安全性。治疗后3个月复查鸦胆子加体部伽玛刀治疗组总有效率和CR均略高于单纯体部伽玛刀治疗组;治疗后白细胞下降率分别为5.6%和23.2%,症状改善率分别为75.5%和45.4%,KPS提高率分别为61.2%和22.5%,组间差异性明显。可见,鸦胆子与体部伽玛刀联合治疗老年非小细胞肺癌,有较好的临床药用价值,既能提高老年非小细胞肺癌的局部控制率,减少体部伽玛刀治疗过程中的副作用,同时能增强机体免疫功能,延长病人生存期,提高生活质量。Objective To study Clinical effect of Ya-Dan-Zi with Body-Gamma Knife intreating Non-small Cell Lung Cancer.Methods Going through clinical, image and psychopathology,160 Non-small Cell Lung Cancer with random division into groups. Principle are divided into Ya-Dan-Zi add Body- Gamma Knife treatment group and merely Body-Gamma Knife treatment group.Results Alter treating check in 3months Ya-Dan-Zi treatment group always effective rate and CR axe higher than merely Body-Gamma Knife treatment group slightly. After treating white cell dropdown to 5.6%and 23.2.%,symptom improvement rateis 75.5% and 45.4% ,KPS improvement rateis 61.2% and 22.5%,the discrepancy of between blocks is obvious.Conclusion Ya-Dan-Zi add Body-Gamma Knife treatment can raise the local control rate of Non-small Cell Lung Cancer, and strengthen organism immunity function.

关 键 词：鸦胆子乳油注射液 体部伽玛刀 老年非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤] R282.71[医药卫生—临床医学]