380例慢性炎性脱髓鞘性多发性神经病临床特征分析  

Clinical Analysis of 380 Patients with Chronic Inflammatory Demyelinating Polyneuropathy

作　　者：尹燕红[1] 李国忠[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经内科,黑龙江哈尔滨150001

出　　处：《中国神经免疫学和神经病学杂志》2009年第4期241-244,共4页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的汇总临床及文献资料,了解中国地区慢性炎性脱髓鞘性多发性神经病(CIDP)的临床特征。方法对380例CIDP患者资料进行回顾性描述分析。结果 CIDP患者男女比2.17:1.00,平均年龄(39.25±12.33)岁,其中68.89%为慢性进展型,22.22%有前驱症状,发病高峰期双下肢受累45.21%,单纯累及双下肢4.90%,肌力远端重于近端者46.53%,植物神经受累17.28%;脑脊液蛋白-细胞分离77.83%;电生理检查F波异常61.05%;糖皮质激素有效率84.03%。结论中国地区CIDP患者平均年龄较同期国外报道早5～10年,且自主神经受累更为多见。Objective To get information of current status in China by analyzing chronic inflammatory demyelinating polyneuropathy （CIDP） data. Methods To analyze clinical features of 380 CIDP cases retrospectively by describing method. Results There were more male patients than female patients （2.17 times） with average age of （39.25±12.33） years and 68.89% of the patients was slowly progression type, 22.22% of them with precursory symptoms. 45.21% suffered both lower extremities during the peak period while 4.9% purely suffered lower extremities, 46.53 % more severe in distal ends, 17.28% autonomic nerve involvements. CSF protein-cell divergence was 77.83%, F wave abnormality was 61.05%, The curative effect was showed in 84.03% patients to glueocorticosteroid therapy. Conclusions The onset age of CIDP was about 5-10 years earlier in China than patients abroad and with more autonomic nerve involvements.

关 键 词：慢性炎性脱髓鞘性多发性神经病 临床分析 

分 类 号：R744.5[医药卫生—神经病学与精神病学]