ω-3多不饱和脂肪酸对老年痴呆大鼠学习记忆和海马MDA、SOD的影响  

Effects of ω-3 Polyunsaturated Fatty Acids on the Ability of Learning and Memory,MDA and SOD of the Hippicampus Tissue in Rats with Senile Dementia

作　　者：赵秀娟[1] 张卫红[1] 孙素娟[1] 李文景[1] 李慧卿 巩涛[1] 吕佩源[1] 

机构地区：[1]河北省人民医院神经内科,河北石家庄050051 [2]河北省石家庄市公安消防支队卫生所,河北石家庄050000

出　　处：《中国神经免疫学和神经病学杂志》2009年第4期273-275,共3页Chinese Journal of Neuroimmunology and Neurology

基　　金：河北省自然科学基金资助项目(301415)

摘　　要：目的探讨ω-3多不饱和脂肪酸治疗老年痴呆的可能机制。方法将1 5月龄健康雌性Wistar大鼠随机分为对照组、痴呆模型组和ω-3多不饱和脂肪酸治疗组[按体质量2.5 g/(kg·d)给予二十碳五烯酸灌胃,共6周],观察大鼠跳台潜伏时间及错误次数,同时测定大鼠海马组织总SOD活力和MDA含量。结果与痴呆模型组比较,ω-3多不饱和脂肪酸治疗组大鼠的跳台潜伏时间明显延长[分别为(230.88±29.35)s与(189.26±31.42)s](P<0.01),触电错误次数减少[分别为(7.3±2.2)次与(9.6±2.2)次](P<0.05),同时其大鼠海马组织总SOD活力增加[分别为(70.19±12.85)U/mg prot与(50.47±14.99)U/mg prot]和MDA含量减少[分别为(7.77±1.57)nmol/mg prot与(9.39±1.44)nmol/mg prot](P<0.05)。结论ω-3多不饱和脂肪酸可改善大鼠学习记忆能力,保护脑组织免遭自由基攻击,在一定程度上为临床治疗老年痴呆提供了实验基础。Objective To investigate the mechanism of ω-3 polyunsaturated fatty acids in senile dementia. Methods The normal 15 months old Wistar rats were randomly divided into the normal control, model group and ω-3 polyunsaturated fatty acids group EEPA 2.5 g/（kg · d） by intragastric administration for 6 weeks]. The escape latency time and mistaken times were evaluated hy using the step down test. The content of malondialdehyde （MDA） and superoxide dismutase （SOD） of the hippicampus tissue in rats were detected. Results Compared with the model group, ω-3 polyunsaturated fatty acids group had lingeringly latency [（230.88±29.35）s vs. （189.26±31.42）s] （P〈0.01） and less error times [（7.3±2.2）times vs. （9.6±2.2）times]（P〈 0.05）. At the same time, ω-3 polyunsaturated fatty acids increased SOD [（70.19±12.85）U/mg prot vs. （50.47±14.99）U/mg prot] and down regulated MDA of the hippieampus in rats [（7.77±1.57）nmol/mg prot vs. （9.39±1.44）nmol/mg prot] （P〈0. 05）. Conclusions ω-3 polyunsaturated fatty acids could improve learningmemory function in rats and protect cerebral tissue against free radical. Also provides the experimental base of treatment with senile dementia.

关 键 词：老年痴呆 学习记忆 Ω-3多不饱和脂肪酸 丙二醛 总超氧化物歧化酶 

分 类 号：R749.16[医药卫生—神经病学与精神病学]