CK17和p16在宫颈鳞状上皮不成熟化生和宫颈上皮内瘤变中的表达及意义  

Expression of CK17 and p16 and their implications in cervical squamous immature metaplasia and cervical intraepithelial neaplasia

作　　者：丁岚[1] 杨永国[1] 梅霞[1] 

机构地区：[1]江都市人民医院病理科

出　　处：《诊断病理学杂志》2009年第3期174-176,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的检测CK17、p16、Ki-67和p63在宫颈鳞状上皮不成熟化生（IM）和宫颈上皮内瘤变（CIN）中的表达和意义。方法应用免疫组化SP法检测宫颈IM15例和CIN30例组织标本中的p16、CK17、p63和Ki-67的表达水平,并对其表达和意义进行分析。结果CK17在宫颈IM中的阳性表达率为100%,明显高于LSIL和HSIL组（10%和15%,P〈0.01） p16在LSIL和HSIL中的表达率均为100%,明显高于IM组（13.3%,P〈0.01） Ki-67的表达在IM和CIN中差异极显著（P〈0.01） p63在宫颈IM和LSIL、HSIL中的阳性表达率均为100%,各组间差别不显著（P〈0.01）。结论CK17和p16在宫颈IM和CIN病变中表达具有明显差异,有助于两种病变的鉴别诊断。Objective To study the expression of CK17 and cervical intraepithelial neaplasia （CIN）. Methods p16, p63 and Ki-67 in cervical squamous immature metaplasia （IM） lmmunohistochemical SP method was used to detect the expression of CK17, p16, p63 and Ki-67 in IM and CIN, and implications of the results were analyzed. Results The positive rate of CK17 in IM was 100%, which was higher than that of LSIL and HSIL （100% and 15%, P〈0.01）; the positive rate of p16 in LSIL and HSIL was both 100%, which were higher than that of IM （13.3%, P 〈 0.01）. And there was obvious difference in the positive rate of Ki-67 between IM and CIN （ P 〈 0.01） ; The positive rates of p63 in LSIL and HSIL were both 100%, which were no difference from that of IM （ 100%, P 〈 0.01）. Conclusion The expression of CK17 and p16 is obviously different in IM and CIN, which could provide assistance for the differential diagnosis between the two cervical lesions.

关 键 词：CK17 P16 宫颈 鳞状上皮不成熟化生 宫颈上皮内瘤变 

分 类 号：R737.33[医药卫生—肿瘤]