血管生成素在视网膜新生血管中的作用  

Role of Angiogenin in Retinal Neovascularization

作　　者：蒋晓萌（综述）[1] 唐宁（审校）[2] 

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]石河子大学医学院第一附属医院,新疆石河子832000

出　　处：《医学综述》2009年第15期2267-2270,共4页Medical Recapitulate

摘　　要：视网膜新生血管形成与眼部多种疾病有关，如糖尿病性视网膜病变、眼底血管栓塞等缺血病变、新生儿视网膜病变等，视网膜新生血管形成以及与其相伴的渗出、出血、增生等一系列病理改变可严重破坏眼的结构和功能，并导致患者不可逆的视功能障碍。多种细胞因子参与新生血管生成的调控，其中血管生成素几乎完全特异于血管内皮细胞。近年来血管生成素在视网膜新生血管生成中的作用逐渐被认识，本文就血管生成素家族成员及其受体在视网膜新生血管生成机制的作用进行综述。Retinal angiogenesis is related to many eye diseases, such as diabetic retinopathy,ischemic diseases including eyegreund embolism, neonatal retinopathy. Retinal neovascularization and a se- ries of pathological changes companied with it can destrpy the function and structure of eye ,which will then result in irreversible disorder of view sight. Many kinds of cytokines take part in the regulation of neovascularization, among which, angiogenin almost act on the vascular endothelium specifically. In re- cent years, the effect of angiogenin is being recognized in the retinal neovascularization. This article reviews the effect of angiogenin about its members and receptors in the retinal neovascularization and possible mechanism.

关 键 词：血管生成素 视网膜新生血管 血管内皮生长因子 

分 类 号：R774.1[医药卫生—眼科]