维生素B_1自组装膜修饰金电极对多巴胺、尿酸的电催化作用  

Electrocatalytic Properties of Dopamine and Uric Acid at Vitamin B_1 Self-assembled Monolayer Gold Electrode

作　　者：杨秋霞[1] 李国宝[1] 张颖[1] 

机构地区：[1]济南大学化学化工学院,济南250022

出　　处：《分析化学》2009年第7期1004-1008,共5页Chinese Journal of Analytical Chemistry

基　　金：济南大学学校基金(No.Y0412)资助项目

摘　　要：用维生素B1(VB1)在金电极上进行自组装,制备了VB1自组装膜修饰金电极(VB1-Au/SAMs/CME)。利用循环伏安法初步研究了此自组装单分子膜修饰电极的电化学行为。结果表明:VB1在金电极表面具有特性吸附。以[Fe(CN)6]3-/4-氧化还原电对为探针,考察了VB1自组装膜修饰金电极的电化学性质,VB1自组装膜的存在对[Fe(CN)6]3-/4-的电子转移具有明显的阻碍作用。研究了多巴胺(DA)和尿酸(UA)在此电极上的电化学行为。实验结果表明,DA和UA在此电极上均可被电催化氧化。差分脉冲伏安(DPV)氧化峰电流与DA浓度在2.0×10-5～4.0×10-4mol/L范围内呈线性关系;测定UA的线性范围为6.0×10-5～2.2×10-4mol/L,而且可实现这两种物质的同时测定。Vitamin B1 self-assembled monolayer modified electrode （VB1-AU/SAMs/CME） was prepared and its electrochemical behavior was studied by cyclic voltammetry. The results showed that a self-assembled monolayer （SAM） was formed on the surface of gold electrode. [ Fe （CN）6 ]^3-/4-redox couple was used as the electrochemical probe to study the electrochemical characteristics of SAM modified gold electrode and the results indicated that the existence of Vitamin B1 membrane on gold surface hindered the electron transfer. The electrochemical behaviors of dopamine（DA） and uric acid （UA） were investigated at VB1-Au/SAMs/CME. The results showed that the electrochemical oxidation of DA and UA could be electrocatalyzed. There were linear relationships between the anodic peak current and the concentration of DA （ 8.0×10^-6- 4.0×10^-4 moL/L） and UA （6.0×10^-5-2.2×10^-4mol/L） respectively in differential pulse voltammograms. This modified electrode was effective to detect DA and UA in simultaneous determination of these species in a mixture.

关 键 词：维生素B1 自组装 多巴胺 尿酸 电催化 化学修饰电极 

分 类 号：R741[医药卫生—神经病学与精神病学]