饮水类型与原发性肝癌的Meta分析  

A Meta-analysis on Source of Drinking Water and Primary Liver Cancer in China

作　　者：李旭东[1] 么鸿雁[1] 阚坚力[1] 

机构地区：[1]中国疾病预防控制中心流行病学办公室,北京100050

出　　处：《中国肿瘤》2009年第7期545-547,共3页China Cancer

摘　　要：[目的]探讨不同饮用水类型与人群原发性肝癌的相关关系。[方法]综合国内1994～2008年关于不同饮用水类型与人群原发性肝癌的病例对照研究和前瞻性定群研究文献,进行Meta分析。[结果]9项病例对照研究共累积病例2603例,对照2880例;1项定群研究,人数为77682例。Meta分析结果显示饮用地表水与原发性肝癌患病的合并比值比OR=1.51(95%CI:1.26～1.80,P<0.01);去除1项定群研究后的合并比值比OR=1.75(95%CI:1.28～2.39,P<0.01),较全部文献的合并危险度稍高。[结论]研究结果表明饮沟塘水、河水、浅井水等浅层地表水是原发性肝癌的危险因素。[Purpose] To investigate the relationship between primary liver cancer （PLC） and source of drinking water. [Methods] Case-control study and prospective cohort study on source of drinking water and PLC from 1994 to 2008 were analyzed by Meta-analysis. [Results] Nine case-control studies with total of 2 603 cases and 2 880 controls, and one cohort study with 77 682 cases were analyzed. The Meta-analysis showed that the odds ratio （OR） of incidence of PLC with drinking surface water was 1.51 （95%CI：1.26-1.80,P〈0.01）. OR was 1.75（95%CI：1.28-2.39,P〈0.01） after excluding a cohort study, which was slightly higher than that in all the literatures. [Conclusion] Pondditch water, river water and shallow well water as drinking water are the risk factors of PLC.

关 键 词：肝肿瘤 饮水 危险因素 META分析 

分 类 号：R735.7[医药卫生—肿瘤]