深圳地区淋球菌营养分型和抗生素耐药性的研究  

Research for Distribution of Auxotypes and Antibiotic Resistance of Neisseria Gonorrboeae in Shenzhen

作　　者：马一婷[1] 宋矿余[2] 王辉[1] 

机构地区：[1]广东省深圳市龙岗中心医院,518116 [2]江西省江西医学院病原微生物学教研室,330006

出　　处：《中国医药指南》2009年第13期12-12,64,共2页Guide of China Medicine

摘　　要：目的了解深圳地区淋球菌的营养型分布和对4种抗生素的耐药性。方法对深圳地区113株淋球菌进行MIC测定和PPNG检测,同时对其中113株淋球菌进行营养分型检测。结果113株菌中检出PPNG菌株9株,TRNG16株,青霉素耐药株73株(64.60%),环丙沙星耐药株88株(77.88%),大观霉素、头孢曲松未发现耐药株。113株淋球菌分16种营养型,以Pro-型、Proto-型、Pro-lle型、Lle-型、Pro-lleSer型5种营养型为主,占86.73%,其余11种营养型占13.27%。结论青霉素和环丙沙星的耐药菌株主要分布于Pro-型中,TRNG菌株主要分布于Lle-型,PPNG菌株散在于各种营养型中。研究结果表明,深圳地区淋球菌的营养型和耐药性的分布状况,有助于本地区淋球菌的流行病学研究和淋病防治。Objective To investigate distribution of auxotypes and antibiotic resistance ofNeisseria gonorrboeae in Shenzhen. Method One hundred and thirteen isolales ofN. gonorrhoeae were determined for MICs and PPNG. Result Among which 113 were auxotyped. It was showed that 9 strains from 113 strains were PPNG, 16 TRNG, 73 penicillin-resistant strains （64.60%）, 131 ciprofloxacin-resistant strains. No strains were found to be spvcfinomycin or ceftriaxone resistang, One hundred and thirteen strains were classified into 16 auxotypes, most of which pertained to such five auxotypes as pro-, proto-, pro- lle-, lle-, pro-Ue-ser-, accounting for 86：73% and the other 11 auxotypes contributed the rest of 13.27%. Conclusion The most of penicillin and ciprofloxacin resistant stains belonged to Pro-, and TRNG strains to Lle-, and PPNG strains showed various auxotypes.The study represented the distribution of auxotypes of N.gonorrhoeae and its susceptibility.It is helpful for the study of epidemiologic research and control of gonorrhea in Shenzhen.

关 键 词：淋病奈瑟菌 营养型 耐药性 

分 类 号：R969.3[医药卫生—药理学]