西帕依固龈液的抑菌作用和防治牙龈炎的临床效果评价  

A study on the effects of Xipayiguyinye on oral bacteria and gingivitis in vitro and in vivo

作　　者：罗颖[1] 丁一[2] 王萌[3] 杨恒[1] 朱硃[2] 

机构地区：[1]四川大学华西口腔医院牙周科 [2]口腔疾病研究国家重点实验室,四川大学 [3]四川大学华西口腔医院病案室,四川成都610041

出　　处：《国际口腔医学杂志》2009年第4期394-397,共4页International Journal of Stomatology

摘　　要：目的观察西帕依固龈液体外抑制牙周可疑致病菌的作用和体内防治牙龈炎的临床疗效。方法用琼脂稀释法测定西帕依固龈液对牙龈卟啉单胞菌、中间普雷沃菌和具核梭杆菌的最低抑菌浓度(MIC);将临床诊断为单纯性牙龈炎的50例患者随机分为实验组和对照组,基线检查后分别给予西帕依固龈液和不含有效成分基质的含漱液漱口,观察使用含漱液漱口7d后两组受试者龈沟出血指数(SBI)和菌斑指数(PLI)的变化。结果西帕依固龈液对牙龈卟啉单胞菌、具核梭杆菌的MIC是1.0g/L,对中间普雷沃菌的MIC是0.5g/L;实验组用药前后的SBI和PLI差异有统计学意义,用药后两组的SBI和PLI差异有统计学意义。结论西帕依固龈液对牙周可疑致病菌具有明显的抑制作用,可减少牙菌斑的堆积、降低SBI和改善牙龈健康。Objective The aim of the present study was to investigate the effects of Xipayiguyinye on oral bacteria in vitro and gingivitis in vivo. It will provide references for the clinical application of Xipayiguyinye. Methods The minimum inhibitory concentration （MIC） of Xipayiguyinye on Porphyromonas gingivalis （P.gingivalis）, PrevoteUa intermedia（P.intermedia） and Fusobacterium nucleatum（F.nucleatum） was observed by agar dilution in vitro. Also, the effects of Xipayiguyinye on gingivitis was investigated on 50 volunteers in vivo. Results It showed in this study the MIC of Xipayiguyinye for P.gingivalis and F.nucleatum was 1.0 g/L, and for P.intermedia was 0.5 g/L. There was significant difference on the sulcus bleeding index（SBI） and plaque index （PLI） before and after taking medication in the trial group （P〈0.05）. Also, there was significant difference on the SBI and PLI between the trial group and the controll group after taking medication. Conclusion It can be concluded from this study that Xipayiguyinye has significant bacteriostasis on P.gingivalis, P.intermedia and F.nucleatum in vitro. It could decrease the accumulation of dental plaque, reduce bleeding index and improve the healthy status of the gingiva in vivo.

关 键 词：西帕依固龈液 抑菌作用 防治 牙龈炎 临床效果 

分 类 号：R781.4[医药卫生—口腔医学]