鳞状细胞癌抗原的研究进展  

Research progress of squamous cell carcinoma antigen

作　　者：冯晓宇[1] 邢汝东[1] 

机构地区：[1]首都医科大学附属口腔医院口腔颌面外科,北京100050

出　　处：《国际口腔医学杂志》2009年第4期429-431,434,共4页International Journal of Stomatology

基　　金：首都医学发展科研基金资助项目(2005-3047)

摘　　要：鳞状细胞癌抗原(SCCA)是从子宫颈鳞状上皮中分离出来的鳞状上皮细胞相关抗原TA-4的亚单位,由SCCA-1和SCCA-2抗原组成。SCCA与鳞状细胞癌的发生发展关系十分密切,是反映鳞状细胞癌生物学特性的重要标志物,被广泛应用于全身各系统肿瘤的研究中。笔者下面就SCCA的结构和功能、在组织和体液中的表达、与肿瘤细胞程序性死亡以及多种鳞状细胞癌的关系等研究进展作一综述。Squamous cell carcinoma antigen （SCCA） is squamous epithelial related antigen TA-4 isolated from cervical squamous epithelium and composed of SCCA-1 and SCCA-2 antigens. SCCA is closely related to carcinogenesis of squamous cell carcinoma and an important marker exhibiting the biological features of SCC, being extensively studied in all kinds of human tumors. This article reviewed the SCCA expression in tissue and body fluids, it＇s relationship with programmed cell death and many kinds of SCC.

关 键 词：鳞状细胞癌 抗原 生物学特性 

分 类 号：R730.3[医药卫生—肿瘤]