糖多孢红霉菌红霉素高产菌种的诱变选育  

Breeding of Erythromycin High-yielding Saccharopolyspora Erythraea Strain

作　　者：孟祥学[1,2] 王凤山[1] 

机构地区：[1]山东大学药学院生化与生物技术药物研究所,山东济南250012 [2]鲁南制药集团股份有限公司,山东临沂276000

出　　处：《食品与药品》2009年第4期35-37,共3页Food and Drug

摘　　要：目的诱变和筛选糖多孢红霉菌(Saccharopolyspora erythraea)红霉素的高产菌种。方法以糖多孢红霉菌L1为出发菌株,紫外线作为诱变剂,诱变和筛选生产所用菌种。结果获得了高产变株L2-26,其发酵水平较出发菌株提高了19.8%。结论此方法可有效地获得高产变株,发酵水平明显提高。Objective To breed erythromycin high-yielding Saccharopolyspora erythraea strain, Methods Saccharopolyspora erythraea strain L1 was used as the starting strain. Mutagenesis was induced by UV. Results The fermentation yield of the resulting erythromycin high-yielding stain L2-26, was 19.8 % higher than that of starting strain. ZConclusion Erythromycin production was increased obviously.

关 键 词：糖多孢红霉菌 高产变株 紫外线诱变 

分 类 号：R978.15[医药卫生—药品]