基质金属蛋白酶-9和增殖细胞核抗原在膀胱移行细胞癌中的表达及相关性  

Expressions and significances of matrix metalloproteinase-9 and proliferating cell nuclear antigen in transitional cell carcinoma of bladder

作　　者：许华[1] 张晓妍[2] 李胜水[1] 张凤梅[1] 李双标[1] 刘岩[1] 

机构地区：[1]河北省沧州中西医结合医院病理科,061001 [2]河北省沧州市中心医院泌尿外科,061001

出　　处：《实用医学杂志》2009年第13期2072-2074,共3页The Journal of Practical Medicine

摘　　要：目的:探讨基质金属蛋白酶-9(MMP-9)和增殖细胞核抗原(PCNA)在膀胱移行细胞癌(BTCC)中的表达及临床意义。方法:采用免疫组织化学SP法,检测58例BTCC和10例正常膀胱组织中MMP-9和PCNA的表达。结果:在10例正常膀胱组织中MMP-9和PCNA呈阴性或弱阳性表达。在58例BTCC中,两者阳性表达率分别为65.5%和69.0%,明显高于正常膀胱组织(P<0.01)。MMP-9、PCNA在低级别BTCC中的阳性表达率分别为35.3%和29.4%,明显低于高级别BTCC的78.0%和85.4%(P<0.01);MMP-9、PCNA在浅表性BTCC中的阳性表达率分别为36.4%和40.9%,明显低于浸润性BTCC的83.3%和86.1%(P<0.01)。MMP-9、PCNA在BTCC中的表达呈正相关(r=0.451,P<0.01)。结论:MMP-9、PCNA在BTCC的发生、分化、浸润和转移过程中发挥重要作用,两者联合检测有利于评估BTCC的恶性程度和预后。Objective To evaluate the expressions and significances of matrix metalloproteinase-9 （MMP-9） and proliferating cell nuclear antigen （PCNA） in bladder transitional cell carcinoma （BTCC）. Method The expressions of MMP-9 and PCNA in 58 cases of BTCC and 10 cases of normal bladder tissues were detected by SP immunohistochemical technique. Results The expression rates of MMP-9 and PCNA were higher in BTCC than those in normal bladder tissues （65.5% and 69.0% vs 0 and 10.0%,P 〈 0.01 ）, and were higher in high grade BTCC than those in low grade BTCC （78.0% and 85.4% vs 35.3% and 29.4%,P〈 0.01）, and were higher in invasive BTCC than those in superficial BTCC （83.3% and 86.1% vs 36.4% and 40.9%, P 〈 0.01 ）. There were positive correlation between the expressions of MMP-9 and PCNA in BTCC （r = 0.451, P 〈 0.01 ）. Conclusion MMP-9 and PCNA may play an important role in the development of BTCC, and combined detection of them may be benefit to evaluating the malignancv and vredicting the proanosis of BTCC.

关 键 词：膀胱肿瘤 明胶酶B 增殖细胞核抗原 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]