组蛋白甲基化修饰与血液恶性肿瘤  

Histone methylation and hematological malignant

作　　者：邹勇(综述)[1] 马旭东(审校)[1] 

机构地区：[1]福建医科大学附属漳州市医院血液科,363000

出　　处：《白血病．淋巴瘤》2009年第7期443-445,共3页Journal of Leukemia & Lymphoma

基　　金：基金项目：卫生部研究基金福建卫生教育联合攻关计划（wkj2008-2-55）;漳州市科学研究发展计划基金（Z07014）;福建医科大学科学研究发展专项基金计划（FZS08018）

摘　　要：暴露在核小体表面的N-末端尾部可发生共价修饰，这些共价修饰可以影响组蛋白和DNA结合的紧密程度，从而影响DNA的表达，被称之为“组蛋白密码”。研究表明组蛋白末端的赖氨酸和精氨酸残基被异常甲基化与血液恶性肿瘤的发生有密切关系。调控组蛋白的甲基化水平，能够抑制细胞周期并诱导血液恶性肿瘤细胞凋亡。The N-terminal tail of histone exposed to the surface of nucleosomes could be covalenfly modificated. Chromatin condensation is controlled by modification of the amino acid residues in the histone tails. The different modifications of amino acids in histones have been suggested to be the＇ histone code＇. It effects functionally on the nuclear processes and DNA expression. A large number of study show that improper change of the state of methylations in lysine and arginine side chains of histone can induce hematological malignant. Modulation of histone methylation can inhibit cell cycle and induce apoptosis in hematological malignant cells.

关 键 词：组蛋白 甲基化 血液恶性肿瘤 

分 类 号：R733[医药卫生—肿瘤] R730.2[医药卫生—临床医学]