不同种类的结膜囊冲洗液对眼表泪膜功能的影响  

Effects of different kinds of conjunctival sac eyewash on ocular surface tear film function

作　　者：黄惠春[1] 林世斌[1] 张少斌[1] 

机构地区：[1]汕头大学.香港中文大学联合汕头国际眼科中心,中国广东省汕头市515041

出　　处：《国际眼科杂志》2009年第7期1305-1306,共2页International Eye Science

基　　金：中国广东省汕头市科技计划资助项目~~

摘　　要：目的:对比50g/L安尔碘Ⅲ型稀释液、5g/L妥布霉素稀释液用于白内障术前结膜囊冲洗时对眼表泪膜功能的影响。方法:选择行白内障超声乳化联合人工晶状体植入术的50例60眼患者,随机分为3组(安尔碘组、妥布霉素组及生理盐水对照组),术前分别用50g/L安尔碘Ⅲ型稀释液、5g/L妥布霉素稀释液、生理盐水冲洗结膜囊,于术前、术后1,7,30d分别行基础泪液分泌试验(SchirmerⅠtest,SⅠt)与泪膜破裂时间(breakup time,BUT)检查。结果:所有患者术后1dBUT与术前相比明显缩短(P<0.01),SⅠt滤纸湿长较术前也明显延长(P<0.01);术后7d,所有患者BUT仍较术前缩短(P<0.01),SⅠt基本恢复至术前水平(P>0.05);术后30d,除妥布霉素组BUT与SⅠt与术前相比仍有异常外(P<0.05),其余两组患者的BUT与SⅠt基本恢复到术前水平(P>0.05);3组间对比除在术后30d妥布霉素组SⅠt低于其他两组外(P<0.05),其余各时间点BUT与SⅠt均不存在组间差异(P>0.05);所有患者术中及术后均未观察到药物性角结膜毒性或过敏反应。结论:50g/L安尔碘Ⅲ型稀释液、5g/L妥布霉素稀释液与生理盐水一样,用于白内障术前结膜囊冲洗时未对眼表泪膜功能造成特殊影响。AIM- To compare the effects of 50g/L anerdian type 3 disinfectant dilution and 5g/L tobramycin dilution to ocular surface tear film function used in conjunctival sac before cataract surgery. METHODS： Fifty cataract patients （60 eyes） who had undergone phacoemulsification aspiration with intraocular lens insertion were included and randomly divided into three groups （anerdian, tobramycin and saline）. The patients in each group were treated with diluted anerdian, tobramycin and saline as eyewash respectively before the surgery. Tear breakup time （BUT） and Schimer Ⅰtest （Sit） value were measured preoperatively and 1 day and 7,30 days postoperatively. RESULTS, On the first postoperative day the mean BUT reduced greatly, and the mean S Ⅰt value increased significantly（P〈0.01） in all patients. 7 days after operation, the mean Sit value returned to their preoperative values（ P〉 0.05） ,but the BUT still reduced. 30 days after operation , the BUT and SⅠ t value were still different to preoperative values in tobramycin group; and in other groups both values returned to their preoperative level. Beside the Sit in tobramycin group was below to others, there were no differences of BUT and S Ⅰ t among three groups pre- operation and 1-day,7-day,30-day after operation. And we disclosed no toxic or allergic reaction postoperatively in all patients. CONCLUSION, There were no changes of tear film when 50g/L anerdian type 3 and 5g/L tobramycin used as eyewash in conjunctival sac before cataract surgery.

关 键 词：结膜囊 冲洗液 泪膜 

分 类 号：R779.6[医药卫生—眼科]