胸段食管癌TN分期的CT表现与p53蛋白的关系  

The relationship between p53 protein and CT manifestation of the TN-staging in thoracic esophageal carcinoma

作　　者：许建生[1] 黄伟鹏[1] 陈洁容[1] 姚沛旭[1] 陈卫鹏[1] 

机构地区：[1]广东省揭阳市人民医院CT室,广东揭阳522000

出　　处：《中国临床医学影像杂志》2009年第7期527-529,540,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:探讨胸段食管癌TN分期的CT表现与p53蛋白表达之间的关系。方法:利用免疫组织化学(SP)法及CT扫描,分析66例经病理确诊的胸段食管癌组织p53蛋白表达与TN分期的CT表现间的关系。结果:经CT分期,T1期3例,T2期10例,T3期41例,T4期12例,淋巴结转移21例。p53蛋白的阳性表达率为51.52%(34/66)。T4期中p53蛋白的阳性表达率高于T3、T1～2期(χ2分别为3.412、3.381,P值均<0.05)。淋巴结转移阳性与阴性组中p53蛋白阳性表达率分别为80.95%(17/21)和37.78%(17/45),二者差异有统计学意义(χ2=10.686,P=0.001)。T1～2、T3、T4期p53蛋白高表达率分别为23.08%(3/13)、46.34%(19/41)、66.67%(8/12),p53蛋白表达强度随着CT的T分期升高而有增强的趋势(rs=0.270,P=0.028)。淋巴结短径≤2cm与短径>2cm组的p53蛋白阳性表达率为84.62%(11/13)、75.00%(6/8),二者差异无统计学意义(P=0.289)。结论:食管癌中较高的p53蛋白表达与CT术前TN分期相关,p53蛋白的表达强度随着CTT分期升高有增强的趋势,淋巴结大小与p53蛋白无关。Objective： To study the relationship between the CT manifestation of the TN-staging and the expressions of p53 protein in thoracic esophageal carcinoma. Methods： p53 protein expressions in esophageal carcinoma and its relationship with the TN-staging by CT were analyzed by means of SP immunohistochemical technique and CT scanning in 66 patients with esophageal carcinoma proved by pathology. Results： There were 3 cases staged as T1, 10 cases as T2, 41 cases as T3, and 12 cases as T4 by CT. Twenty-one cases were detected to have lymph nodes metastases. The positive-expression rate of p53 protein was 62.12%（41/66）. The positive-expression rate of p53 protein in T4-stage was remarkably higher than that in T1- 2 and T3-stage（X^2=3.412, P〈0.05, and X^2=3,381, P〈0,05）. The positive-expression rate of p53 protein in cases with and without lymph nodes metastasis was 80.95%（17/21） and 37.78%（17/45） respectively, their difference was statistically significant （X^2= 10.686, P=0.001）. The high expression rate of p53 protein in group T1-2, T3 and T4 was 23.08%（3/13）, 46.34%（19/41）, 66.67% （8/12） respectively. The expression intensity of p53 protein was increasing in accordance with the rise of T-staging （rs=0.270, P=0.028）. The positive-expression rate of p53 protein in cases with lymph nodes metastases （short axis diameter~〈2cm） was 84.62%（11/13）, in mediastinal lymph nodes metastases（short axis diameter〉2cm） was 75.00%（6/8）. Their difference was not statistically significant （P=-0.289）. Conclusion： The high expressions of p53 protein were correlated to CT TN-staging. The expression intensity of p53 protein is increasing in accordance with the rise of T-staging. There was no correlation between the size of lymph nodes metastases and the expressions of p53 protein.

关 键 词：食管肿瘤 蛋白质P53 体层摄影术 X线计算机 

分 类 号：R735.1[医药卫生—肿瘤] R814.42[医药卫生—临床医学]