bFGF和CD105在胃癌组织中的表达及其生物学行为  

bFGF and CD105 in gastric carcinoma and its biological behavior

作　　者：曹永清 刘青山[2] 张莉 陈辉 

机构地区：[1]湖南省长沙市第一医院肿瘤血液科,湖南长沙410005 [2]湘南学院附属医院内科 [3]湖南省长沙市第一医院病理科

出　　处：《中国医师杂志》2009年第7期899-901,共3页Journal of Chinese Physician

摘　　要：目的探讨缄性成纤维细胞生长因子（bFGF）和CD105在胃癌组织中的表达及其生物学行为。方法采用免疫组化检测60例胃癌组织及20例正常胃组织中bFGF与微血管密度（MVD）的表达和胃癌细胞增殖指数（SPF）。用TUNEL原位凋亡法检测胃癌组织中胃癌细胞凋亡，计算凋亡率（AR）。结果胃癌组织中bFGF蛋白表达、MVD、SPF明显高于正常胃组织，而AR低于正常胃组织。bFGF、MVD和SPF呈正相关（r=0．48、0．51、0．46，P〈0．05）。bFGF和MVD与AR呈负相关（r=-0．44、-0．47、0．43，P〈0，05）。结论bFGF可能通过上调MVD的表达，从而促进胃癌细胞增殖，抑制胃癌细胞凋亡。Objective To investigate basic fibroblast grow th factor （bFGF） and CD105 in gastric carcinoma and its biological behavior. Methods bFGF, microvessel density （MVD） and stomach cancer cell S phase fraction （SPF） in 60 samples from stomach cancer patients and 20 samples from normal stomach were detected with immunohistochemistry.. Apoptosis in stomach cancer was determined with TUNEL and apoptosis rate （AR） was calculated. Results bFGF protein expression, MVD and SPF in stomach cancer patients were obviously higher than that normal health controls, but AR were lower, bFGF and MVD showed positive relationship with SPF, and negative with AR. Conclusion bFGF possibly increased the MVD state, promoted stomach cancer cell multiplication, suppressed stomach cancer cell apoptosis.

关 键 词：成纤维细胞生长因子2/生物合成 血管细胞粘附分子-1/生物合成 胃肿瘤/代谢 

分 类 号：R735.2[医药卫生—肿瘤] R644[医药卫生—临床医学]