胃癌组织中COX-2与VEGF、MMP-2、P-糖蛋白的表达及意义  

The expression of COX-2, VEGF, MMP-2 and P-glucoprotein in carcinoma of stomach and its significance

作　　者：田琳[1] 杨虹 

机构地区：[1]黑龙江省医院消化内科,黑龙江哈尔滨150036 [2]黑龙江省哈尔滨市红十字中心医院普内科

出　　处：《中国医师杂志》2009年第7期917-918,共2页Journal of Chinese Physician

摘　　要：目的探讨胃癌组织中COX-2与VEGF、MMP-2及P-糖蛋白的表达及意义。方法应用免疫组织化学方法检测57例胃癌及其癌旁组织中COX-2与VEGF、MMP-2及P-糖蛋白的表达情况。结果COX-2、VEGF、MMP-2与P-糖蛋白在胃癌组织中的表达均高于癌旁组织，其结果差异有统计学意义（χ^2=5．29，5．37，5．62，4．87；P〈0．05）；COX-2、VEGF、MMP-2在不同转移情况胃癌组织中的表达差异有统计学意义（χ^2=5．97，6．17，6．09；P〈0．05）；COX-2与VEGF、MMP-2及P-糖蛋白在胃癌组织中的表达呈正相关（χ^2=0．67，0．65，0．67；P〈0．05）。结论胃癌组织中COX-2与VEGF、MMP-2及P-糖蛋白处于过度表达状态且具有相关性，可能参与胃癌的发生、发展及癌细胞的多药耐药。Objective To investigate the expression of COX-2, VEGF, MMP-2 and P-glycoprotein in carcinoma of stomach and its significance. Method The expressions of COX-2, VEGF and P-glycoprotein inside and beside the tumor tissues of 57 cases carcinoma of stomach were detected with immunohistochemistry method. Result The expressions of COX-2, VEGF, MMP-2 and P-glycoprotein inside the tumor tissues were significantly higher than that beside the tumor（ χ^2 = 5.29,5.37,5.62,4. 87; P 〈 0. 05 ）. The expressions of COX-2, VEGF and MMP-2 were different among different carcinoma metastasis （ χ^2 = 5.97, 6. 17,6.09 ; P 〈 0. 05 ）. P-glucoprotein expressions were positive correlated with gastric cancer（ χ^2 = 0. 674,0. 65,0. 67 ; P 〈 0. 05）. Conclusion COX-2, VGEF, MMP-2 and P-glycoprotein were some correlated and overexpressed in stomach carcinoma, which may take part in the genesis, development and multi - drug resistance of this cancer.

关 键 词：胃肿瘤/代谢 前列腺素内过氧化物合酶/生物合成 明胶酶A/生物合成 血管内皮生长因子类/生物合成 P糖蛋白/生物合成 

分 类 号：R735.2[医药卫生—肿瘤] R737.9[医药卫生—临床医学]