沉默信息调节因子1在肿瘤形成中的作用机制  

Mechanism of SIRT1 acting on tumor formation

作　　者：冯安宁[1] 樊祥山[1] 黄勤[1] 张丽华[1] 

机构地区：[1]南京医科大学鼓楼临床医学院病理科,江苏南京210008

出　　处：《医学研究生学报》2009年第7期767-769,共3页Journal of Medical Postgraduates

基　　金：南京市医学科技发展重点项目基金资助(批准号:ZKX07011)

摘　　要：沉默信息调节因子1(SIRT1)是烟碱胺腺嘌呤二核苷酸(NAD+)依赖的组蛋白去乙酰化酶,参与细胞衰老、凋亡、分化等生理活动。近来研究表明,SIRT1通过对组蛋白及多种非组蛋白的去乙酰化修饰,调节与肿瘤凋亡、增殖等多种相关基因的表达和蛋白质的活性,参与肿瘤形成和发展。SIRT1 is an NAD^＋ -dependent histone deacetylase, involved in many physiological processes, such as cell aging, apoptosis and differentiation. Recent studies have shown that SIRT1 plays a significant role in tumor formation and progression. It deacetylates a wide range of histone and non-histone substrates and regulates gene expression and protein activity that are associated with neoplastic apoptosis and proliferation.

关 键 词：沉默信息调节因子1 去乙酰化 肿瘤形成 

分 类 号：R730.21[医药卫生—肿瘤]