自体外周血干细胞移植治疗多发性骨髓瘤8例疗效观察  

Therapeutic effect of autologous peripheral blood stem cell transplantation for eight cases with mutiple myeloma

作　　者：王煜[1] 刘林[1] 张红宾[1] 肖青[1] 

机构地区：[1]重庆医科大学附属第一医院血液科,400016

出　　处：《重庆医学》2009年第14期1742-1743,共2页Chongqing medicine

摘　　要：目的评价自体外周血干细胞移植（APBSCT）治疗多发性骨髓瘤（MM）的疗效。方法本院自2006年12月至2009年4月，对8例接受APBSCT治疗MM患者，采用化疗联合G-CSF动员，当WBC〉5．0×10^9／L时开始采集APBSC，采用大剂量马法兰（200mg／m^2）进行预处理。结果所有患者的造血均快速重建。1例患者出现发热，3例患者出现肝功异常，无1例死亡。移植后随访2～29个月，共7例患者获得CR，其中1例在获得CR后5个月病情复发，另有1例患者仍为NR。结论自体外周血干细胞移植是治疗多发性骨髓瘤安全有效的方法，患者耐受性好，尤其对移植前获得CR或PR的患者治疗效果较好。Objective To evaluate the effect of autologous peripheral stem cell transplantation （APBSCT） on multiple myeloma. Methods Eight cases with multiple myeloma receiving APBSCT were included from December 2006 to April 2009. Combined chemotherapy followed by G-CSF was used for mobilization regimen. APBSC were collected when white blood cell （WBC）〉5.0×10^9/L. The conditioning regimen was high-dose melphalan （200mg/m^2 ）. Results All patients were engrafted and gained rapid hematopoietic reconstitution. Of the patients, fever was observed in one and abnormalities of hepatic transaminase were observed in three. Nobody died. With a follow-up time of 2 to 29 months,seven patients achieved complete remission （CR） ,of which the disease relapsed in one patient five months later. One patient had no response （NR）. Conclusion APBSCT is a safe and efficient therapy for multiple myeloma and is tolerated well. The therapeutic effect of APBSCT is better on the patients with CR or PR.

关 键 词：自体外周血干细胞移植 多发性骨髓瘤 

分 类 号：R733.3[医药卫生—肿瘤] R457.7[医药卫生—临床医学]