辅助自体真皮移植修复腭前瘘的实验研究  

Rehabilitation of the front palate fistula with adjuvant derma transplantation in Japanese big ear rabbits

作　　者：卢明星[1] 胡黎萍[1] 陈菲[1] 童昕[1] 

机构地区：[1]南京大学医学院附属口腔医院口腔颌面外科,210008

出　　处：《实用口腔医学杂志》2009年第4期517-520,共4页Journal of Practical Stomatology

摘　　要：目的:观察辅助真皮移植修复腭前瘘的治疗效果,为缺乏周围及邻近组织为特点的腭前瘘修复提供一种方法。方法:用手术的方法,建立日本大耳兔腭前部口鼻瘘模型。术后1月,实验组采用周围的组织翻转作衬里及背部真皮移植修复腭瘘;对照组仅用周围组织翻转作鼻腔衬里修复腭瘘。观察腭前瘘愈合情况及1、2周组织学改变。结果:移植修复腭前瘘的真皮片均成活,实验组腭前瘘修复效果较好,而对照组修复成功率相对较低。结论:辅助真皮移植修复兔腭前瘘提高了治愈成功率,为临床解决缺乏周围邻近组织为特点的腭前瘘修复提供了一种选择。Objective： To study the rehabilitation efficiency of adjuvant derma transplantation in treatment of front palate fistula. To find a better way to solve the problem of correcting the front fistula in short of the nearby tissue. Methods ： Established the front fistula model in the oral and nasal cavity in the front of the palate with surgery. 30 Japanese big ear rabbits were divided into 2 groups. One month after operation, 15 rabbits were operated with the nearby tissue into the inner of nasal cavity and by transplanting their back skin while the others were treated only with the nearby tissues. The rehabilitation process and the histological changes of the palate were observed. Results： All dermal flaps survived after transplantation. This surgical method got a satisfying effect（ P 〈 0.05 ）. The rate of success for correcting with single nearby tissues was lower. Conclusion： Adjuvant derma transplantation for re- habilitation of the front palate fistula is effective and reliable in the rabbits. The combination of the nearby tissue and homeochronous derma transplantation might be a good mode for correcting the front fistula in short of the nearby tissues.

关 键 词：口鼻瘘 真皮移植 辅助治疗 

分 类 号：R782.22[医药卫生—口腔医学]