急性心肌梗死缝隙连接重构与干细胞移植治疗  

Gap junction remodeling and stem cell transplantation following acute myocardial infarction

作　　者：柯红红[1] 钟国强[1] 

机构地区：[1]广西医科大学第一附属医院心内科,广西心血管病研究所,广西壮族自治区南宁市530021

出　　处：《中国组织工程研究与临床康复》2009年第19期3747-3750,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目(项目批准号30560051);广西留学回国人员科学基金资助项目(桂科回0448014);广西医疗卫生重点科研课题资助项目(桂卫重200301)~~

摘　　要：心脏缝隙连接作为心肌细胞间介导点和化学信号的特殊通道,构成心脏缝隙连接的缝隙连接蛋白,缝隙连接蛋白数量及分布等改变引起的心脏缝隙连接重构与急性心肌梗死后心室重构及心律失常的发生。现已发现心脏缝隙连接重构是急性心肌梗死后心律失常发生的重要原因和病理学基础之一。如何增加心肌细胞数量和减轻或逆转心脏缝隙连接重构,成为关注的焦点。近年来兴起的急性心肌梗死细胞移植疗法中,干细胞因其自我更新、可分化为祖细胞和某一子代细胞的能力而受到科学家的重视。文章就心脏缝隙连接的结构、功能、分布及心肌梗死后心脏缝隙连接重构及干细胞移植疗法的基础及临床研究作一综述。Gap junctions （GJ） form the chemical signal channels between cardiocytes, The core proteins of these channels are the connexins （Cx）. The quantity or distribution of Cx will lead to the remodeling of GJ, which contributed to arrhythmia and remodeling following the acute myocardial infarction. GJ remodeling is the key reason and pathological basis of arrhythmia following acute myocardial infarction. How to increase the number of myocardial cells and lighten or reverse the heart reconstitution have become a focal point. In the acute myocardial infarction cell transplantation treatment, stern cells are characterized by self-renewal and multi-directional differentiation have been paid great attention. This study summarized the basis and clinical research of GJ structure, function, distribution, remodeling and stem cell transplantation treatment following myocardial infarction.

关 键 词：急性心肌梗死 缝隙连接蛋白 骨髓间充质干细胞 移植 心肌细胞 

分 类 号：R394.2[医药卫生—医学遗传学]