淋巴靶向性MR造影剂Dextran—Gd—DTPA对兔腘窝VX2肉瘤转移性淋巴结的诊断价值  

Role of Dextran-Gd-DTPA-enhanced MR lymphography in diagnosing VX2 tumor-bearing lymph node

作　　者：杨炼[1] 徐海波[1] 孔祥泉[1] 冯敢生[1] 鄢国平[2] 陈立波[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院,武汉430022 [2]武汉工程大学材料系

出　　处：《中华实验外科杂志》2009年第8期1075-1076,共2页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（30672067、30700190）;教育部新世纪优秀人才资助计划（NCET-07-318）

摘　　要：目的探讨新型淋巴靶向造影剂Dextran-Gd-DTPA对良、恶性淋巴结的鉴别诊断价值。方法取12只新西兰大白兔（24个腘窝淋巴结）分成2组：正常组及VX2肉瘤腘窝淋巴结肿瘤转移组各6只。经双侧趾蹼间隙注射Dextran—Gd-DTPA后行MR增强扫描，计算标准化信号强度（sI）和增强率（En％）。同时在体外检测Dextran-Gd-DTPA溶液中质子的自旋-晶格弛豫时间T1并计算R1值。结果Dextran-Gd-DTPA的T1值为0．03556s，R1值为33．37·L（mmol·s）^-1。正常组淋巴结明显强化，增强率约100％；VX2肉瘤转移性淋巴结表现为强化不明显，增强率为23％，两组差异有统计学意义。结论Dextran-Gd-DTPA经组织间隙给药明显增强正常淋巴结，转移性淋巴结强化效应不明显，这种新型MR造影剂对鉴别良恶性淋巴结有重要价值。Objective To evaluate the role of a new contrast agent Dextran-Gd-DTPA in distin-guishing regional normal or tumor-beating （VX2 tumor） lymph nodes. Methods The lymphographic contrast agent Dextran-Gd-DTPA is a macromolecular gadohnium complex. Lymphographic effects were investigated in normal and tumor-bearing rabbits after interstitial injection. The amount of contrast agent uptake in the nodes as E% were measured after the injection. And experimental data of relaxivity was measured in vitro. Results T1 of Dextran-Gd-DTPA is 0.035 56 s and R1 is 33.37 · L （ mmol · s）^ -1. After interstitial injection, Dextran-Gd-DTPA accumulates in regional lymph nodes, resulting in a pronounced increase of signal intensity in normal lymph nodes （100%） but less in tumor-bearing lymph node（ 23% ）, which was significantly different （P 〈 0.05 ）. Conclusion Dextran-Gd-DTPA is an innovative contrast agent that can distinguish between normal and tumorous lymph nodes in interstitial MR lvmnhooranhy.

关 键 词：淋巴结造影 造影剂 肉瘤 

分 类 号：R73-3[医药卫生—肿瘤]