脑功能区胶质瘤手术唤醒麻醉中持续或间断输注舒芬太尼的影响  

Target Controlled or Intermittent Infusion of Sufentanil during Awake Craniotomy

作　　者：程灏[1] 王德祥[1] 韩如泉[1] 

机构地区：[1]首都医科大学附属北京天坛医院麻醉疼痛科,北京市100050

出　　处：《中国康复理论与实践》2009年第7期679-680,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家重点基础研究发展计划(973计划)(2007CB512503)

摘　　要：目的比较神经外科唤醒麻醉中持续或间断输注舒芬太尼对呼吸和循环的影响。方法脑功能区胶质瘤择期开颅手术患者40例,分为A组(n=20)和B组(n=20),分别采取间断或持续输注舒芬太尼的方法行唤醒麻醉。记录术中用药量及呼吸和循环相关指标。结果B组舒芬太尼用药量明显大于A组(P<0.01),呼吸频率低于A组(P<0.05),呼气末CO2浓度高于A组(P<0.05)。结论在脑功能区占位手术唤醒麻醉中,间断给予舒芬太尼在不增加静脉麻醉药用量并保证镇痛效果的前提下降低镇痛药的用药量,减轻呼吸抑制的发生。Objective To compare the efficacy and safety of the target controlled administration of sufentanil and intermittent sufentanil during awake craniotomy. Methods 40 patients were randomized into target controlled infusion of sufentanil group （n= 20） and intermittent sufentanil group （n=20） and compared. Results The hemodynamie parameters were similar in the two groups. However, target controlled infusion of sufentanil was associated with significantly lower respiratory rate （P〈0.05）, higher end tidal CO2 （P〈0.05）, and higher dosage of sufentanil （P〈0. 01）, compared with those of intermittent sufentanil. Conclusion Intermittent sufentanil infusion is associated with less respiratory depression than target controlled administration of sufentanil in awake craniotomy.

关 键 词：脑功能区 胶质瘤 唤醒麻醉 舒芬太尼 呼吸抑制 

分 类 号：R730.264[医药卫生—肿瘤]