可乐定透皮贴剂治疗儿童抽动-秽语综合征的疗效观察  

Efficacy of clonidine transdermal patch for treatment of Tourette's syndrome in children

作　　者：康华[1] 张月芳[2] 焦富勇[1] 郭向阳[1] 高晓敏[1] 

机构地区：[1]陕西省人民医院儿科,陕西西安710068 [2]陕西省人民医院儿保科,陕西西安710068

出　　处：《中国当代儿科杂志》2009年第7期537-539,共3页Chinese Journal of Contemporary Pediatrics

摘　　要：目的目前对儿童抽动-秽语综合征（TS）的治疗主要以口服药物为主，但鉴于药物的不良反应及每日1-2次口服药物不方便，导致患儿依从性差。该文探讨可乐定透皮贴剂治疗TS的临床疗效和安全性。方法将119例5-17岁TS患儿分为两组，治疗组65例采用可乐定透皮贴剂；对照组54例给予氟哌啶醇口服。4周后观察两组的疗效。疗效评定采用耶鲁大体抽动严重程度量表（YGTSS）测定。结果贴剂治疗组YGTSS减分率（61.5±7.5）%，对照组减分率（41.0±6.3）%，两组减分率通过χ^2检验差异有显著性（P〈0.05）。贴剂治疗组53例有效，有效率为81.5%，对照组36例有效，有效率为67.5%，差异无显著性。贴剂治疗组1例出现血压下降、头晕反应，停药后恢复。对照组2例出现轻度的颈肌张力增高，4例出现轻度嗜睡，疲乏。结论可乐定透皮贴剂对治疗儿童TS有明显疗效，且不良反应少而轻微，方便，易于接受。Objective Children with Tourette＇s syndrome （TS） have a poor treatment compliance due to side effects and inconvenient administration of oral drugs. This study explored the efficacy and safety of clonidine transdermal patch for treating TS in children. Methods A total of 119 children with TS were randomly treated with the clonidine transdermal patch （n = 65） or with oral haloperidol （n = 54）. The therapeutic efficacy was assessed based on the results of the Yale Global Tic Severity Scale （ YGTSS ） 4 weeks after treatment. Results The clonidine transdermal patch group showed a higher reduction in the overall tic symptom scores （ 61.5 ± 7.5% ） than that in the haloperidol group （41.0± 6.3% ; P 〈0.05）. Clonidine transdermal patch treatment was effective in 53 patients （81.5%） and 36 patients （67.5%） showed effective to oral haloperidol （ P 〉 0.05 ）. Mild side effects （ decrease of blood pressure and dizziness ） were observed in 1 patient in the clonidine transdermal patch group. Mild hypermyotonia, drowsiness or lassitude as side effects occurred in 6 patients in the haloperidol group. Conclusions Clonidine transdermal patch is effective for the treatment of TS in children and its side effects are mild and rare.

关 键 词：可乐定透皮贴剂 氟哌啶醇 抽动-秽语综合征 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]