超选择性子宫动脉化疗栓塞治疗宫颈癌的临床价值  

Super-selective uterine artery chemoembolization for the treatment of cervical cancer:its clinical value

作　　者：朱赤[1] 张德志[1] 曹立宇[2] 熊壮[1] 汪名权[1] 杜临安[1] 赵本胜[1] 王万勤[1] 盛强[1] 余永强[1] 

机构地区：[1]合肥安徽医科大学第一附属医院放射科,230022 [2]合肥安徽医科大学第一附属医院病理科,230022

出　　处：《介入放射学杂志》2009年第7期507-509,共3页Journal of Interventional Radiology

摘　　要：目的探讨超选择性子宫动脉化疗栓塞治疗宫颈癌的临床价值。方法对病理证实的56例宫颈癌患者先行双侧子宫动脉灌注化疗,化疗药物为DDP、EADM/THP、MMC和5-Fu;然后采用碘油乳剂和明胶海绵栓塞子宫动脉。6例介入治疗后行根治术。结果56例均行双侧子宫动脉栓塞。术中造影显示子宫动脉明显增粗,肿瘤滋养血管呈螺旋状,肿瘤染色明显。本组治疗总有效率为94.6%。6例术后2周行子宫根治术+盆腔淋巴结清扫术,术中出血量减少,手术时间缩短,其中1例术中发现单侧卵巢坏死。主要不良反应为白细胞下降、恶心、呕吐和腹痛。结论超选择性子宫动脉化疗栓塞治疗宫颈癌是安全有效的辅助治疗方法,并发症发生率低。Objective To evaluate super-selective uterine arterial chemoembolization therapy in the treatment of cervical cancer. Methods Bilateral uterine arterial infusion with DDP, EADM or THP, MMC and 5-Fu was performed in 56 patients with pathologically-proved cervical cancer, which was followed by embolization of uterine arteries with iodine emulsion and Gelfoam particles. Radical hysterectomy was performed in 6 patients after interventional treatment. Results Embolization of bilateral uterine arteries were successfully carried out in all cases. The angiography conducted during the procedure revealed markedly dilated uterine arteries, spiral tumor-feeding arteries and obvious tumor staining. The total effective rate was up to 94.6%. Six patients received radical hysterectomy 2 weeks after arterial chemoembolization, and the blood loss during the operation was much less than usual and the surgery procedure took shorter time. Ovarian necrosis was found in 1 case. The main adverse effects included leukocytopenia, nausea, vomiting and abdominal pain. Conclusion Super-selective uterine arterial chemoembolization is a safe and effective supplementary therapy for cervical carcinoma with fewer complications.

关 键 词：宫颈癌 栓塞 治疗性 不良反应 

分 类 号：R737.33[医药卫生—肿瘤]