细丝蛋白A在浸润性乳腺癌中的表达及意义  

Expression of filamin A in invasive breast carcinoma and its significance

作　　者：吴艳萍[1,2] 李京彬[3] 赵瑞景[4] 王小玲[5] 单保恩[6] 朱铁年[1] 

机构地区：[1]河北医科大学第四医院内分泌科,石家庄050011 [2]河北大学基础医学院病理教研室,保定071000 [3]河北大学护理学院,保定071000 [4]河北医科大学基础医学院免疫教研室,石家庄050017 [5]河北医科大学第四医院病理科,石家庄050011 [6]河北医科大学第四医院科研中心,石家庄050011

出　　处：《肿瘤》2009年第7期659-662,共4页Tumor

基　　金：河北省卫生厅医学科学研究重点课题计划项目(编号:08155)

摘　　要：目的:探讨细丝蛋白A(filamin A,FLNa)在浸润性乳腺癌组织中的表达及其与临床特征之间的关系。方法:采用免疫组织化学和FCM法检测46例浸润性乳腺癌标本中FLNa的表达情况,并统计分析FLNa表达与患者临床病理学特征的相互关系。结果:FLNa在浸润性乳腺癌组织中的表达水平随分化程度的降低而增高,中、高分化组与低分化组之间的差异有统计学意义(P<0.05);有淋巴结转移组的FLNa表达水平较无淋巴结转移组高(P<0.05)。结论:FLNa表达水平与浸润性乳腺癌的侵袭和转移有关,可作为浸润性乳腺癌预后判断的辅助指标,也有望成为临床治疗的新靶点。Objective ：To study the relationship between the expression of filamin A （FLNa） and clinical pathological features in invasive breast carcinoma. Methods：The expression of FLNa was measured by immunohistochemistry and flow cytometry in 46 cases of invasive breast carcinoma. Results： The expression level of FLNa was increased in poorly differentiated invasive breast carcinoma. There were significant differences between well-moderately differentiated and poorly differentiated groups （P〈0.05）. The expression level of FLNa in invasive breast carcinoma with lymph node metastasis was higher than that in non-metas-tasis group（P〈0.05）. Conclusion ： The level of FLNa expression correlated with invasion and metastasis of invasive breast carcinoma. FLNa can be used as an assistant marker for prediction of breast carcinoma prognosis and has the potential to be a new target for cilinical therapy.

关 键 词：乳腺肿瘤 微丝蛋白质类 免疫组织化学 肿瘤侵润 

分 类 号：R737.9[医药卫生—肿瘤]