脂肪间充质干细胞移植治疗阿尔茨海默病(英文)  

Adipose derived mesenchymal stem cell transplantation for Alzheimer’s disease

作　　者：牛颖[1] 龚锴[1] 敖强[1] 赵南明[2] 张秀芳[1] 公衍道[1] 

机构地区：[1]清华大学生物科学与技术系,北京市100084 [2]清华大学医学院,北京市100084

出　　处：《中国组织工程研究与临床康复》2009年第27期5389-5392,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：Tsinghua-Yue-Yuen Medical Sciences Fund, No. 20240000514;the Beijing Science and Technology Commission Foundation, No. H060920050430;a grant from the State Key Laboratory of Biomembrane and Membrane Biotechnology~~

摘　　要：阿尔茨海默病是一种神经退行性疾病,其典型特征是进行性神经元缺失,迄今为止还没有一种药物和治疗方法对其彻底根治。随着干细胞技术与理论的发展和完善,阿尔茨海默病的治疗研究主要集中在神经干细胞移植方面。为避免免疫反应,最好用自体干细胞进行移植,而获取自体神经干细胞是非常困难的。与神经干细胞相比,间充质干细胞具有更广泛的来源,可以从肝脏、骨髓、脂肪等多种组织中获得,且具有多向分化潜能的特质,在一定诱导条件下可分化为骨、肌肉、脂肪等多种组织,其中脂肪间充质干细胞因其具有容易获得、对患者损伤小等特性而备受关注。新近研究显示,脂肪间充质干细胞具有神经分化潜能,预测其很可能在阿尔茨海默病治疗中发挥重要作用。Alzheimer＇s disease is an irreversible neurodegenerative disease characterized by progressive neuronal loss. To date, there has been no effective medicine or therapy for neurodegenerative disease. With development of stem cell technique and theory, neural stem cell transplantation has been found to be prospective in Alzheimer＇s disease treatment. However, it was challenged by the deficiency of autologous neural stem cell, which can bypass immunological barrier. Compared with neural stem cells, mesenchymal stern cells exhibit extensive resources, such as liver, bone marrow and adipose, and multiple differentiations into bone, muscle or adipose. Considering the easy access, the minor trauma to the patients, and the neuron differentiation potential of adipose derived mesenchymal stem cells （A-MSC）, we hypothesize that A-MSC graft is a potential and innovative strategy for the treatment of Alzheimer＇s disease.

关 键 词：脂肪间充质干细胞 移植 阿尔茨海默病 

分 类 号：R394.2[医药卫生—医学遗传学]