人脂肪源间充质干细胞治疗ABO血型不合造血干细胞移植后的顽固性单纯红细胞再生障碍性贫血2例(英文)  

Human adipose tissue-derived mesenchymal stem cells for treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation

作　　者：李玉富[1,2] 李宁[2] 宋永平[2] 张龚莉 林全德[2] 魏旭东[2] 房佰俊[2] 

机构地区：[1]郑州大学第一附属医院消化内科,河南省郑州市450052 [2]河南省肿瘤医院,河南省血液病研究所,河南省郑州市450008

出　　处：《中国组织工程研究与临床康复》2009年第27期5397-5400,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：Excellent Youth Foundation of Henan Scientific Committee, No. 0612000900~~

摘　　要：回顾性分析2004-04/2006-02河南省血液病研究所收治的2例接受异基因造血干细胞移植后并发单纯红细胞再生障碍性贫血的患者,病例1为一处于第2次完全缓解期的25岁女性急性淋巴细胞白血病患者;病例2为一处于第2次完全缓解状态的16岁女性急性髓细胞白血病患者。均经中心静脉输入脂肪源间充质干细胞进行治疗,剂量为1.0×106/kg。结果2例接受脂肪源间充质干细胞治疗的患者病情很快得以缓解,且均无明显不良反应出现。提示应用脂肪源间充质干细胞治疗ABO血型不合造血干细胞移植后出现的顽固性单纯红细胞再生障碍性贫血有一定的疗效。The present study retrospectively analyzed 2 patients suffering from refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem ceil transplantation who received treatment in the Henan Institute of Haematology between April 2004 and February 2006. Patient 1 was a 25-year-old female with acute lymphocytic leukemia in second remission, and patient 2 was a 16-year-old girl with acute myeloid leukaemia in second remission. The two patients received a transplant of human adipose tissue-derived mesenchymal stem cells （1.0×10^6/kg）. Both of them acquired rapid recovery from pure red cell aplasia without any side effects. These findings suggest that adipose tissue-derived mesenchymal stem cells seem to be a promising therapeutic option in patients with refractory pure red cell aplasia after ABO-incompatible hematopoietic stem cell transplantation, in whom conventional treatment fails.

关 键 词：造血干细胞移植 单纯红细胞再生障碍性贫血 间充质干细胞 

分 类 号：R394.2[医药卫生—医学遗传学]